Research advances in the treatment of arthritis from natural products (2014-present)

IF 4 2区医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE

Chinese Journal of Natural Medicines Pub Date : 2025-05-01 DOI:10.1016/S1875-5364(25)60862-4

Ruilin Wang , Cen Ji , Jiayao Chen , Xiaohan Zhang , Qinghua Hu , Chunxiao Liu

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引用次数: 0

Abstract

Arthritis, encompassing osteoarthritis (OA), rheumatoid arthritis (RA), and gouty arthritis (GA), is a prevalent inflammatory disease that significantly impacts quality of life. Natural products (NPs), derived from animals, plants, marine organisms, and microorganisms, have demonstrated beneficial effects in arthritis treatment both domestically and internationally. These natural compounds offer advantages in drug discovery due to their skeletal diversity, structural complexity, and multi-effect, multi-target, and low-toxicity properties compared to conventional small-molecule medicines. However, unclear mechanisms have hindered the development and clinical application of NPs. This review summarizes recent experimental studies from the past decade on natural medicine for arthritis treatment, emphasizing key NPs with therapeutic effects on OA, RA, and GA. It examines the effects and molecular mechanisms of NPs acting on different cells to treat arthritis. Furthermore, this review provides insights into the future prospects of NP research in this field, which is crucial for advancing NP-based arthritis treatments.

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天然产物治疗关节炎的研究进展（2014-至今）

关节炎，包括骨关节炎（OA），类风湿性关节炎（RA）和痛风性关节炎（GA），是一种普遍的炎症性疾病，显著影响生活质量。从动物、植物、海洋生物和微生物中提取的天然产物（NPs）已经在国内外证明了对关节炎治疗的有益作用。与传统的小分子药物相比，这些天然化合物由于其骨骼多样性、结构复杂性、多作用、多靶点和低毒性而在药物发现方面具有优势。然而，目前尚不清楚的机制阻碍了NPs的发展和临床应用。本文综述了近十年来天然药物治疗关节炎的实验研究，重点介绍了对OA、RA和GA具有治疗作用的关键NPs。它检查了NPs作用于不同细胞治疗关节炎的作用和分子机制。此外，本文综述了该领域NP研究的未来前景，这对于推进基于NP的关节炎治疗至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Chinese Journal of Natural Medicines INTEGRATIVE & COMPLEMENTARY MEDICINE-PHARMACOLOGY & PHARMACY

CiteScore

7.50

自引率

4.30%

发文量

2235

期刊介绍： The Chinese Journal of Natural Medicines (CJNM), founded and sponsored in May 2003 by China Pharmaceutical University and the Chinese Pharmaceutical Association, is devoted to communication among pharmaceutical and medical scientists interested in the advancement of Traditional Chinese Medicines (TCM). CJNM publishes articles relating to a broad spectrum of bioactive natural products, leading compounds and medicines derived from Traditional Chinese Medicines (TCM). Topics covered by the journal are: Resources of Traditional Chinese Medicines; Interaction and complexity of prescription; Natural Products Chemistry (including structure modification, semi-and total synthesis, bio-transformation); Pharmacology of natural products and prescription (including pharmacokinetics and toxicology); Pharmaceutics and Analytical Methods of natural products.