Increasing Serum Vitamin D Levels Reduces Gingival Crevicular Fluid Matrix Metalloproteinase-9 Levels in Periodontal Health and Diseases

IF 6.8 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Clinical Periodontology Pub Date : 2025-05-15 DOI:10.1111/jcpe.14175

Vusal Gurbanov, Ayla Öztürk, Fatma Doğruel, Hatice Saraçoğlu, Cevat Yazıcı

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引用次数: 0

Abstract

Aims

To investigate whether restoring serum vitamin D levels in a population requiring supplementation affects matrix metalloproteinase-9 (MMP-9) levels in the gingival crevicular fluid (GCF) of individuals with periodontal health, gingivitis and periodontitis.

Materials and Methods

This prospective cohort study enrolled 101 participants with vitamin D deficiency, including those with periodontitis (34) and gingivitis (34) and healthy individuals (33). The periodontal status was evaluated using radiographic and clinical assessments of probing depth, clinical attachment loss, gingival index and plaque index. The analysis of MMP-9 levels in the GCF collected from the same dental sites was performed at baseline and 1 month post supplementation.

Results

After 1 month of vitamin D supplementation, a significant decrease in GCF MMP-9 levels was observed across all groups, with the most notable reduction observed in the periodontitis group. The healthy group exhibited the highest percentage reduction at 47%. Linear regression analysis confirmed that changes in vitamin D levels and pocket depth influenced MMP-9 alterations in the GCF.

Conclusions

Restoration of vitamin D levels in vitamin D-deficient patients to the recommended average level (30 ng/mL), according to established guidelines, led to decreased MMP-9 levels in individuals with different periodontal statuses (healthy, gingivitis or periodontitis), potentially mitigating periodontal risks.

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提高血清维生素D水平可降低牙周健康和疾病中的龈沟液基质金属蛋白酶-9水平。

目的研究在需要补充维生素D的人群中恢复血清维生素D水平是否会影响牙周健康、牙龈炎和牙周炎患者牙龈沟液（GCF）中基质金属蛋白酶-9 （MMP-9）水平。材料和方法本前瞻性队列研究招募了101名维生素D缺乏症患者，包括牙周炎患者（34人）和牙龈炎患者（34人）以及健康个体（33人）。通过x线片和临床牙周探查深度、临床附着丧失、牙龈指数和菌斑指数评估牙周状况。在基线和补充后1个月，分析从相同牙齿部位收集的GCF中的MMP-9水平。结果补充维生素D 1个月后，各组GCF MMP-9水平均显著下降，其中牙周炎组下降最为显著。健康组减少的百分比最高，为47%。线性回归分析证实，维生素D水平和口袋深度的变化影响了GCF中MMP-9的变化。结论：根据现有的指南，将维生素D缺乏患者的维生素D水平恢复到推荐的平均水平（30 ng/mL），可以降低不同牙周状态（健康、牙龈炎或牙周炎）患者的MMP-9水平，从而潜在地减轻牙周风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Clinical Periodontology 医学-牙科与口腔外科

CiteScore

13.30

自引率

10.40%

发文量

175

审稿时长

3-8 weeks

期刊介绍： Journal of Clinical Periodontology was founded by the British, Dutch, French, German, Scandinavian, and Swiss Societies of Periodontology. The aim of the Journal of Clinical Periodontology is to provide the platform for exchange of scientific and clinical progress in the field of Periodontology and allied disciplines, and to do so at the highest possible level. The Journal also aims to facilitate the application of new scientific knowledge to the daily practice of the concerned disciplines and addresses both practicing clinicians and academics. The Journal is the official publication of the European Federation of Periodontology but wishes to retain its international scope. The Journal publishes original contributions of high scientific merit in the fields of periodontology and implant dentistry. Its scope encompasses the physiology and pathology of the periodontium, the tissue integration of dental implants, the biology and the modulation of periodontal and alveolar bone healing and regeneration, diagnosis, epidemiology, prevention and therapy of periodontal disease, the clinical aspects of tooth replacement with dental implants, and the comprehensive rehabilitation of the periodontal patient. Review articles by experts on new developments in basic and applied periodontal science and associated dental disciplines, advances in periodontal or implant techniques and procedures, and case reports which illustrate important new information are also welcome.