RNF186 gene variant and zonulin levels in inflammatory bowel disease: A pilot study

IF 1.1 4区医学 Q4 GASTROENTEROLOGY & HEPATOLOGY

Arab Journal of Gastroenterology Pub Date : 2025-05-01 DOI:10.1016/j.ajg.2025.02.005

Elif Özdemir Güneri , Resul Kahraman , Merve Nur Ataş , Arzu Ergen

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引用次数: 0

Abstract

Background and study aim

Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract characterized by inflammation and ulceration of the intestinal mucosa, represented by Crohn’s disease (CD) and ulcerative colitis (UC). The aim of this study is to investigate the relationship between the Ring Finger Protein 186 (RNF186) rs3806308 variant and IBD, as well as to determine whether zonulin levels are associated with IBD.

Patients and methods

Ninety-nine patients with inflammatory bowel disease were included in the study. The real-time PCR method was used to detect RNF186 gene polymorphism. Also serum zonulin levels were determined by using Enzyme Linked Immunosorbent Assay (ELISA) technique.

Results

No difference was found between the groups in terms of RNF186 genotype and allele distributions (p > 0.05). CC genotype was associated with high levels of C-reactive protein (CRP) in total patients and CD compared to CT (p < 0.05).

Conclusion

The present study is the first study conducted in our country in terms of examining RNF 186 gene polymorphism and serum zonulin levels.

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炎症性肠病的RNF186基因变异和zonulin水平：一项初步研究

背景与研究目的：炎症性肠病（IBD）是一种以肠黏膜炎症和溃疡为特征的胃肠道慢性炎症性疾病，以克罗恩病（CD）和溃疡性结肠炎（UC）为代表。本研究旨在探讨Ring Finger Protein 186 (RNF186) rs3806308变异与IBD之间的关系，并确定zonulin水平是否与IBD相关。患者和方法：99例炎症性肠病患者纳入研究。采用实时荧光定量PCR法检测RNF186基因多态性。同时采用酶联免疫吸附试验（ELISA）测定血清zonulin水平。结果：各组间RNF186基因型及等位基因分布差异无统计学意义（p < 0.05）。与CT相比，CC基因型与总患者c反应蛋白（CRP）和CD的高水平相关(p)。结论：本研究是国内首次检测RNF 186基因多态性和血清zonulin水平的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Arab Journal of Gastroenterology Medicine-Gastroenterology

CiteScore

2.70

自引率

0.00%

发文量

期刊介绍： Arab Journal of Gastroenterology (AJG) publishes different studies related to the digestive system. It aims to be the foremost scientific peer reviewed journal encompassing diverse studies related to the digestive system and its disorders, and serving the Pan-Arab and wider community working on gastrointestinal disorders.