Impact of Comorbid Asthma on Life Quality of Patients with Chronic Rhinosinusitis and Nasal Polyps.

IF 3 3区医学 Q2 ALLERGY

Journal of Asthma and Allergy Pub Date : 2025-04-17 eCollection Date: 2025-01-01 DOI:10.2147/JAA.S517258

Pei-Wen Wu, Po-Hung Chang, Chi-Che Huang, Ta-Jen Lee, Yu-Hsi Fan, Chien-Chia Huang

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Abstract

Objective: This study aimed to characterize the clinical features of patients with comorbid asthma and chronic rhinosinusitis with nasal polyps and to evaluate the impact of comorbid asthma on the quality of life of these patients.

Methods: Adult patients with bilateral chronic rhinosinusitis with nasal polyps scheduled for sinus surgery were prospectively enrolled. Clinical information of the participants, including laboratory data and computed tomography images. The Sinonasal Outcome Test-22 was used to evaluate nasal symptoms and quality of life impairment of participants.

Results: A total of 170 participants were recruited, of whom 32 (18.8%) had comorbid asthma. Compared to patients with chronic rhinosinusitis with nasal polyps and without comorbid asthma, patients with asthma exhibited significant higher age, computed tomography ethmoid/maxillary ratio, computed tomography olfactory cleft opacification score, serum total IgE, serum eosinophil cationic protein levels, and blood and tissue eosinophil count. Patients with comorbid chronic rhinosinusitis with nasal polyps and asthma exhibited significant higher total, and rhinologic- and sleep-related domains of the Sinonasal Outcome Test-22 than did those without comorbid asthma.

Conclusion: Comorbid asthma is associated with more severe type 2 eosinophilic inflammation and has a significant impact on the nasal symptoms and quality of life of patients with chronic rhinosinusitis with nasal polyps, particularly as shown in the rhinologic- and sleep-related domains of the Sinonasal Outcome Test-22. This information may assist physicians in decision-making when treating these patients.

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哮喘合并症对慢性鼻窦炎鼻息肉患者生活质量的影响。

目的：探讨哮喘合并慢性鼻窦炎合并鼻息肉患者的临床特征，并评价哮喘合并鼻窦炎对患者生活质量的影响。方法：前瞻性纳入拟行鼻窦手术的双侧慢性鼻窦炎合并鼻息肉的成年患者。参与者的临床信息，包括实验室数据和计算机断层扫描图像。使用鼻窦预后测试-22来评估参与者的鼻部症状和生活质量损害。结果：共招募了170名参与者，其中32名（18.8%）患有共病哮喘。与合并鼻息肉的慢性鼻窦炎患者相比，哮喘患者的年龄、ct筛/上颌比值、ct嗅裂混浊评分、血清总IgE、血清嗜酸性粒细胞阳离子蛋白水平、血液和组织嗜酸性粒细胞计数均显著高于合并鼻息肉的慢性鼻窦炎患者。合并慢性鼻窦炎并鼻息肉和哮喘的患者在鼻窦预后测试22中表现出显著高于未合并哮喘的患者。结论：哮喘合并症与更严重的2型嗜酸性粒细胞炎症相关，并对慢性鼻窦炎伴鼻息肉患者的鼻症状和生活质量有显著影响，特别是在鼻窦预后测试（Sinonasal Outcome test）的鼻和睡眠相关领域22中显示。这些信息可以帮助医生在治疗这些患者时做出决策。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Asthma and Allergy Medicine-Immunology and Allergy

CiteScore

5.30

自引率

6.20%

发文量

185

审稿时长

16 weeks

期刊介绍： An international, peer-reviewed journal publishing original research, reports, editorials and commentaries on the following topics: Asthma; Pulmonary physiology; Asthma related clinical health; Clinical immunology and the immunological basis of disease; Pharmacological interventions and new therapies. Although the main focus of the journal will be to publish research and clinical results in humans, preclinical, animal and in vitro studies will be published where they shed light on disease processes and potential new therapies.