{"title":"Tertiary lymphoid organs in human atherosclerotic plaques","authors":"Devadatta Gosavi, Klaus Ley","doi":"10.1038/s44161-025-00645-x","DOIUrl":null,"url":null,"abstract":"The discovery of plaque tertiary lymphoid organs (PTLOs) within human atherosclerotic plaques provides insights into the role of the immune system in atherosclerosis. The findings highlight the cellular and molecular features of PTLOs, and suggest a potential role of PTLOs in driving plaque instability by activating adaptive immune responses.","PeriodicalId":74245,"journal":{"name":"Nature cardiovascular research","volume":"4 5","pages":"500-502"},"PeriodicalIF":10.8000,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature cardiovascular research","FirstCategoryId":"1085","ListUrlMain":"https://www.nature.com/articles/s44161-025-00645-x","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
引用次数: 0
Abstract
The discovery of plaque tertiary lymphoid organs (PTLOs) within human atherosclerotic plaques provides insights into the role of the immune system in atherosclerosis. The findings highlight the cellular and molecular features of PTLOs, and suggest a potential role of PTLOs in driving plaque instability by activating adaptive immune responses.