{"title":"ARID5A promotes inflammation and fibrosis during cardiac aging","authors":"Shoval Miyara, Eldad Tzahor","doi":"10.1038/s44161-025-00621-5","DOIUrl":null,"url":null,"abstract":"A systematic biology approach identifies an RNA-binding protein, ARID5A, as a regulator of inflammation and fibrosis in the aging human heart. Inhibition of ARID5A reduced inflammation and fibrosis and improved cardiac function in old mice.","PeriodicalId":74245,"journal":{"name":"Nature cardiovascular research","volume":"4 5","pages":"508-510"},"PeriodicalIF":10.8000,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature cardiovascular research","FirstCategoryId":"1085","ListUrlMain":"https://www.nature.com/articles/s44161-025-00621-5","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
引用次数: 0
Abstract
A systematic biology approach identifies an RNA-binding protein, ARID5A, as a regulator of inflammation and fibrosis in the aging human heart. Inhibition of ARID5A reduced inflammation and fibrosis and improved cardiac function in old mice.