Fenghe Xu, Dylan Treger, Xiaoxiao Jia, Mizhou Hui, Zhaohui Ma
{"title":"Analgesic and Curative Effects of 35kDa Hyaluronan Fragment on Zoster-Associated Pain: A Case Report of Two Patients.","authors":"Fenghe Xu, Dylan Treger, Xiaoxiao Jia, Mizhou Hui, Zhaohui Ma","doi":"","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Herpes zoster-associated pain (ZAP) is a challenging neuropathic condition. Clinical reports suggest that a 35kDa hyaluronan fragment (HA35) may effectively relieve this pain with a single local injection. However, evidence of a complete cure is limited.</p><p><strong>Case report: </strong>Two patients were treated-one with acute shingles pain diagnosed 10 days prior, and one with postherpetic neuralgia (PHN) diagnosed a year ago. Pain scores before treatment were 7 for Patient 1, and 4 (average) and 8 (most severe) for Patient 2. Clinicians administered varying doses of HA35 based on pain level and disease duration. Both patients reported significantly reduced Visual Analog Scale pain scores and notable improvements in mental state, appetite, and sleep quality.</p><p><strong>Conclusions: </strong>HA35 not only safely and effectively alleviates and cures ZAP, including acute pain and PHN, without causing side effects, but also improves related issues, such as appetite, sleep, and daily interactions affected by pain.</p>","PeriodicalId":520525,"journal":{"name":"Pain medicine case reports","volume":"9 1","pages":"51-54"},"PeriodicalIF":0.0000,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pain medicine case reports","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Herpes zoster-associated pain (ZAP) is a challenging neuropathic condition. Clinical reports suggest that a 35kDa hyaluronan fragment (HA35) may effectively relieve this pain with a single local injection. However, evidence of a complete cure is limited.
Case report: Two patients were treated-one with acute shingles pain diagnosed 10 days prior, and one with postherpetic neuralgia (PHN) diagnosed a year ago. Pain scores before treatment were 7 for Patient 1, and 4 (average) and 8 (most severe) for Patient 2. Clinicians administered varying doses of HA35 based on pain level and disease duration. Both patients reported significantly reduced Visual Analog Scale pain scores and notable improvements in mental state, appetite, and sleep quality.
Conclusions: HA35 not only safely and effectively alleviates and cures ZAP, including acute pain and PHN, without causing side effects, but also improves related issues, such as appetite, sleep, and daily interactions affected by pain.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
