Investigating fibrinogen levels as a biomarker for immune inflammation severity in COPD patients across GOLD stages.

IF 0.8 4区医学 Q3 MEDICINE, GENERAL & INTERNAL

Journal of the Pakistan Medical Association Pub Date : 2025-04-01 DOI:10.47391/JPMA.11531

Sajjad Ali, Ishtiaq Ahmad

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引用次数: 0

Abstract

Objectives: To assess the association between fibrinogen levels and immune inflammation severity in patients with chronic obstructive pulmonary disease at different stages of the Global Initiative for Chronic Obstructive Lung Disease classification.

Methods: The descriptive, prospective, cross-sectional study was conducted from January 2022 to November 2023 at the Pulmonology Department, Mardan Medical Complex, Khyber Pakhtunkhwa, Pakistan, and comprised chronic obstructive pulmonary disease patients of either gender aged 40-85 years. Fibrinogen levels and systemic immuneinflammatory markers were measured, and disease severity was classified based on the Global Initiative for Chronic Obstructive Lung Disease classification. Independent predictors of fibrinogen levels as well as the diagnostic accuracy of biomarkers for predicting advanced chronic obstructive pulmonary disease were identified. Data was analysed using SPSS 26.

Results: Of the 253 patients, 147(58.10%) were males and 106(41.89%) were females. Most of the patients were aged 40-50 years 72(28.45%), followed by 50-60 years 57(22.52%). A strong positive correlation was observed between fibrinogen levels and chronic obstructive pulmonary disease severity (r=0.815, p<0.001). The diagnostic accuracy of fibrinogen for predicting advanced disease stages was reliable, having an area under the curve of 0.910.

Conclusions: Fibrinogen levels could be used as a marker for immune inflammation severity in chronic obstructive pulmonary disease patients.

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研究纤维蛋白原水平作为COPD患者GOLD分期免疫炎症严重程度的生物标志物。

目的：评估全球慢性阻塞性肺疾病分类倡议不同阶段慢性阻塞性肺疾病患者纤维蛋白原水平与免疫炎症严重程度之间的关系。方法：描述性、前瞻性、横断面研究于2022年1月至2023年11月在巴基斯坦开伯尔-普赫图赫瓦省马尔丹医疗中心肺病科进行，研究对象包括40-85岁的慢性阻塞性肺病患者。测量纤维蛋白原水平和全身免疫炎症标志物，并根据全球慢性阻塞性肺疾病分级计划对疾病严重程度进行分类。确定了纤维蛋白原水平的独立预测因子以及预测晚期慢性阻塞性肺疾病的生物标志物的诊断准确性。数据采用SPSS 26进行分析。结果：253例患者中，男性147例（58.10%），女性106例（41.89%）。40 ~ 50岁以72例（28.45%）最多，50 ~ 60岁以57例（22.52%）次之。纤维蛋白原水平与慢性阻塞性肺疾病严重程度呈显著正相关（r=0.815）。结论：纤维蛋白原水平可作为慢性阻塞性肺疾病患者免疫炎症严重程度的标志。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of the Pakistan Medical Association Medicine-General Medicine

CiteScore

1.10

自引率

11.10%

发文量

983

审稿时长

3-6 weeks

期刊介绍： Primarily being a medical journal, JPMA publishes scholarly research focusing on the various fields in the areas of health and medical education. It publishes original research describing recent advances in health particularly clinical studies, clinical trials, assessments of pathogens of diagnostic importance, medical genetics and epidemiological studies. Review articles highlighting importance of various issues in the domain of public health, drug research and medical education are also accepted. As a leading journal of South Asia, JPMA remains cognizant of the recent advances in the rapidly growing fields of biomedical sciences, it invites and encourages scholars to write short reviews and invited editorials on the emerging issues. We particularly aim to promote health standards of developing countries by encouraging manuscript submissions on issues affecting the public health and health delivery services.