{"title":"Breast cancer susceptibility is associated with Cyclin D1 single nucleotide polymorphisms in Iran: A case-control study.","authors":"Sadaf Soleimani, Soheila Talesh Sasani, Zivar Salehi, Fereshteh Fakour","doi":"10.22099/mbrc.2025.51763.2065","DOIUrl":null,"url":null,"abstract":"<p><p>Breast cancer (BC) is the main cause of cancer-related death in women worldwide. We evaluated the association between the key <i>CCND1</i> gene variant; rs9344 (G>A); and BC risk in Iran. In this case-control study, blood samples were obtained from 58 patients and 66 healthy controls. Genotyping was conducted by tetra-primer amplification refractory mutation system PCR (T-ARMS-PCR). Statistical analysis was performed by MedCalc software. Our results showed that the polymorphism rs9344 has an association with BC risk in the Iranian population. Based on the codominant and recessive models, carriers of the AA genotype are nearly 3.5 times more susceptible to BC than other individuals, and the AA genotype of <i>CCND1</i> A870G may be a significant factor for breast cancer. Further studies are needed to clarify the roles of <i>CCND1</i> polymorphism, rs9344, in breast cancer.</p>","PeriodicalId":19025,"journal":{"name":"Molecular Biology Research Communications","volume":"14 3","pages":"199-202"},"PeriodicalIF":1.5000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12046365/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Molecular Biology Research Communications","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.22099/mbrc.2025.51763.2065","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Breast cancer (BC) is the main cause of cancer-related death in women worldwide. We evaluated the association between the key CCND1 gene variant; rs9344 (G>A); and BC risk in Iran. In this case-control study, blood samples were obtained from 58 patients and 66 healthy controls. Genotyping was conducted by tetra-primer amplification refractory mutation system PCR (T-ARMS-PCR). Statistical analysis was performed by MedCalc software. Our results showed that the polymorphism rs9344 has an association with BC risk in the Iranian population. Based on the codominant and recessive models, carriers of the AA genotype are nearly 3.5 times more susceptible to BC than other individuals, and the AA genotype of CCND1 A870G may be a significant factor for breast cancer. Further studies are needed to clarify the roles of CCND1 polymorphism, rs9344, in breast cancer.
期刊介绍：
“Molecular Biology Research Communications” (MBRC) is an international journal of Molecular Biology. It is published quarterly by Shiraz University (Iran). The MBRC is a fully peer-reviewed journal. The journal welcomes submission of Original articles, Short communications, Invited review articles, and Letters to the Editor which meets the general criteria of significance and scientific excellence in all fields of “Molecular Biology”.
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