The role of vitamin D and the VDR gene polymorphism in sepsis risk and mortality: a systematic review.

IF 2.1 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
Wiwi Jaya, Sumarno Reto Prawiro, Hani Susianti, Aswoco Andyk Asmoro
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Abstract

Objectives: Vitamin D regulates immune function, cell proliferation, and differentiation. Its deficiency is linked to sepsis, although the causal relationship remains unclear. Studies suggest a strong correlation between FokI polymorphism and sepsis in the context of vitamin D deficiency. This study examined the association between vitamin D levels, the VDR FokI polymorphism, and sepsis risk through a systematic review and meta-analysis.

Methods: Relevant articles from 2014-2024 were identified from various databases, including PubMed, Scopus, and Cochrane. A meta-analysis was conducted to assess the difference in vitamin D levels between the sepsis and control groups, as well as the relationship between VDR FokI genotypes (TT, CT, CC) and sepsis risk.

Results: Vitamin D levels in sepsis patients were consistently lower than in the control group, with a mean difference of -4.17 ng/mL (95% confidence interval, -7.87 to -0.47; p=0.03). However, the relationship between VDR FokI genotype and sepsis risk was not statistically significant (p>0.05), although several individual studies showed a positive correlation. High heterogeneity was found in the analysis of vitamin D levels (I²=100%) and FokI genotypes (I²=91%), which affected the interpretation of the results.

Conclusion: Vitamin D deficiency is a potential risk factor for sepsis, while the relationship between the VDR FokI polymorphism and sepsis risk requires further investigation. These findings highlight the importance of early detection of vitamin D deficiency as a preventive strategy in at-risk populations, although additional studies with more standardized designs are needed to definitively confirm this relationship.

维生素D和VDR基因多态性在败血症风险和死亡率中的作用:一项系统综述。
目的:维生素D调节免疫功能、细胞增殖和分化。它的缺乏与败血症有关,尽管因果关系尚不清楚。研究表明,在维生素D缺乏的情况下,FokI多态性与败血症之间存在很强的相关性。本研究通过系统回顾和荟萃分析,研究了维生素D水平、VDR FokI多态性和败血症风险之间的关系。方法:从PubMed、Scopus、Cochrane等数据库中检索2014-2024年的相关文章。进行荟萃分析以评估败血症组和对照组之间维生素D水平的差异,以及VDR FokI基因型(TT、CT、CC)与败血症风险之间的关系。结果:败血症患者的维生素D水平持续低于对照组,平均差异为-4.17 ng/mL(95%可信区间,-7.87至-0.47;p = 0.03)。然而,VDR FokI基因型与脓毒症风险之间的关系无统计学意义(p>0.05),尽管有个别研究显示两者呈正相关。在维生素D水平(I²=100%)和FokI基因型(I²=91%)分析中发现高度异质性,这影响了结果的解释。结论:维生素D缺乏是脓毒症的潜在危险因素,VDR FokI多态性与脓毒症风险的关系有待进一步研究。这些发现强调了早期检测维生素D缺乏症作为高危人群预防策略的重要性,尽管需要更多标准化设计的额外研究来明确证实这种关系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Osong Public Health and Research Perspectives
Osong Public Health and Research Perspectives Medicine-Public Health, Environmental and Occupational Health
CiteScore
10.30
自引率
2.30%
发文量
44
审稿时长
16 weeks
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