Effect of serum IL-6, CRP, and MMP-9 levels on the efficacy of modified preperitoneal Kugel repair in patients with inguinal hernia.

IF 1.7 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Open Medicine Pub Date : 2025-04-23 eCollection Date: 2025-01-01 DOI:10.1515/med-2024-1066

Lifang Li, Renjie Cui, Wanli Ma, Kunhou Yao

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引用次数: 0

Abstract

Objective: To evaluate the effect of serum IL-6, C-reactive protein (CRP), and matrix metalloproteinase-9 (MMP-9) levels on the efficacy of modified preperitoneal Kugel repair in patients with inguinal hernia.

Methods: Clinical records of 42 patients with inguinal hernias who underwent modified preperitoneal Kugel repair were retrospectively analyzed. Serum IL-6, CRP, and MMP-9 were detected before surgery and after surgery. The patients were divided into the corresponding high-expression group and low-expression group. The basic data and clinical characteristics of patients were analyzed and compared, as well as postoperative indexes.

Results: In patients with inguinal hernia, serum IL-6, CRP, and MMP-9 increase first and then decrease after surgery, reaching the peak value around 24 or 48 h after surgery. Patients with high-expression of IL-6, CRP, and MMP-9 had longer hospital stays and time to return to normal activities, and were more likely to have chronic abdominal pain. In addition, high-expression of IL-6 and CRP had a higher probability of postoperative VAS values and wound infection, and high-expression of IL-6 and MMP-9 were also more likely to have wound healing injuries.

Conclusions: Serum IL-6, CRP, and MMP-9 levels in patients with inguinal hernia can affect the efficacy of modified preperitoneal Kugel repair and the prognosis of patients.

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血清IL-6、CRP、MMP-9水平对腹股沟疝改良腹膜前Kugel修复术疗效的影响

目的：探讨血清IL-6、c反应蛋白（CRP）、基质金属蛋白酶-9 （MMP-9）水平对改良腹膜前Kugel修复术治疗腹股沟疝疗效的影响。方法：回顾性分析42例腹股沟疝行改良腹膜前Kugel修补术的临床资料。术前、术后检测血清IL-6、CRP、MMP-9。将患者分为相应的高表达组和低表达组。分析比较两组患者的基本资料、临床特点及术后指标。结果：腹股沟疝患者术后血清IL-6、CRP、MMP-9先升高后降低，在术后24 ~ 48 h左右达到峰值。IL-6、CRP和MMP-9高表达的患者住院时间更长，恢复正常活动的时间更长，并且更容易出现慢性腹痛。此外，高表达的IL-6和CRP有更高的术后VAS值和伤口感染的概率，高表达的IL-6和MMP-9也更容易出现伤口愈合损伤。结论：腹股沟疝患者血清IL-6、CRP、MMP-9水平可影响改良腹膜前Kugel修复术的疗效及患者预后。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Open Medicine Medicine-General Medicine

CiteScore

3.00

自引率

0.00%

发文量

153

审稿时长

20 weeks

期刊介绍： Open Medicine is an open access journal that provides users with free, instant, and continued access to all content worldwide. The primary goal of the journal has always been a focus on maintaining the high quality of its published content. Its mission is to facilitate the exchange of ideas between medical science researchers from different countries. Papers connected to all fields of medicine and public health are welcomed. Open Medicine accepts submissions of research articles, reviews, case reports, letters to editor and book reviews.