Efficacy of Home-Based Remotely Supervised Transcranial Direct Current Stimulation for Managing Neuropsychiatric Symptoms in Older Adults With Alzheimer's Disease and Related Dementias.

Integrative and complementary therapies Pub Date : 2024-10-01 Epub Date: 2024-10-21 DOI:10.1089/ict.2024.21943.jp

Juyoung Park, Chiyoung Lee, Lifeng Lin, James Galvin, Mindy J Fain, Angela Allen, Lindsey Park, Hyochol Ahn

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Abstract

Background: Neuropsychiatric symptoms (NPS) are prevalent among persons with Alzheimer's disease and related dementias (ADRD). However, there are limited safe and effective nonpharmacological treatments for controlling NPS. Transcranial direct current stimulation (tDCS) is a promising noninvasive and safe treatment.

Materials and methods: This study investigated the effects of remotely supervised tDCS in managing NPS in older adults with mild to moderate ADRD. Forty older adults diagnosed with early-stage ADRD were randomly assigned in a 1:1 ratio to receive home-based active tDCS (n = 20) or sham tDCS (n = 20).

Results: Results showed a significantly greater improvement in the following NPS: scratching (P = 0.052, Hedges' g = -0.60 [confidence interval {CI}: -1.24, 0.04], Cliff's δ = -0.41 [CI: -0.67, -0.06]), nighttime behaviors (P = 0.041; Hedges' g = -0.62 [CI: -1.26, 0.03]; Cliff's δ = -0.41 [CI: -0.67, -0.06], and appetite/eating changes (P = 0.010; Hedges' g = -0.78 [CI: -1.43, -0.13]; Cliff's δ = -0.41 [CI: - 0.56, -0.10]).

Conclusion: This study shows promising initial results for using home-based, remotely supervised tDCS to manage NPS, such as nighttime behaviors, changes in eating and appetite, and scratching. Larger studies with more participants are needed to explore various tDCS doses and their long-term effects on NPS.

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家庭远程监督经颅直流电刺激治疗老年阿尔茨海默病及相关痴呆患者神经精神症状的疗效

背景：神经精神症状（NPS）在阿尔茨海默病及相关痴呆（ADRD）患者中普遍存在。然而，控制NPS的安全有效的非药物治疗方法有限。经颅直流电刺激（tDCS）是一种很有前途的无创、安全的治疗方法。材料和方法：本研究调查了远程监督tDCS在管理轻度至中度ADRD老年人NPS中的作用。40名诊断为早期ADRD的老年人按1:1的比例随机分配，接受基于家庭的主动tDCS （n = 20）或假tDCS （n = 20）。结果：结果显示，在以下NPS方面有显著改善：抓挠（P = 0.052， Hedges的δ = -0.60[置信区间{CI}: -1.24, 0.04]， Cliff的δ = -0.41 [CI: -0.67, -0.06]），夜间行为(P = 0.041；对冲系数g = -0.62 [CI: -1.26, 0.03]；Cliff’s δ = -0.41 [CI: -0.67, -0.06]，食欲/饮食变化(P = 0.010；对冲系数g = -0.78 [CI: -1.43, -0.13]；Cliff’s δ = -0.41 [CI: - 0.56, -0.10])。结论：这项研究显示了使用基于家庭、远程监督的tDCS来管理NPS的初步结果，如夜间行为、饮食和食欲的变化以及抓挠。需要有更多参与者的更大规模的研究来探索不同的tDCS剂量及其对NPS的长期影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Integrative and complementary therapies

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