Plasma TAR DNA-binding protein 43 (TDP-43) levels in a population-based cohort of older adults: The cardiovascular health study.

IF 3.4 3区医学 Q2 NEUROSCIENCES

Journal of Alzheimer's Disease Pub Date : 2025-04-23 DOI:10.1177/13872877251334820

Alison E Fohner, Colleen M Sitlani, Suman Jayadev, Joshua C Bis, Emily H Trittschuh, Oscar L Lopez, Russel P Tracy, Bruce M Psaty, W T Longstreth, Sudha Seshadri

引用次数: 0

Abstract

Brain deposition of transactive response DNA-binding protein 43 (TDP-43) is a feature of neurodegenerative syndromes. We evaluated TDP-43 plasma concentrations in 1058 participants in the Cardiovascular Health Study (CHS), a population-based longitudinal cohort. The cohort was 38% male, 11% Black, had a mean age 75 years, and 261 people developed dementia over a mean of 5.5 years of follow up. Median TDP-43 levels were 211.0 pg/mL (IQR: 134.0-341.0 pg/mL). TDP-43 levels were not associated with cross-sectional or longitudinal change in cognitive scores, with plasma AD biomarkers, with brain MRI volumes, with incident dementia, or with demographic characteristics.

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老年人血浆TAR dna结合蛋白43 （TDP-43）水平：心血管健康研究

脑沉积的交互反应dna结合蛋白43 （TDP-43）是神经退行性综合征的一个特征。我们评估了1058名心血管健康研究（CHS）参与者的TDP-43血浆浓度，这是一项基于人群的纵向队列研究。研究对象中男性占38%，黑人占11%，平均年龄为75岁，在平均5.5年的随访中，有261人患上了痴呆症。中位TDP-43水平为211.0 pg/mL （IQR: 134.0-341.0 pg/mL）。TDP-43水平与认知评分的横截面或纵向变化、血浆AD生物标志物、脑MRI体积、痴呆事件或人口统计学特征无关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Alzheimer's Disease 医学-神经科学

CiteScore

6.40

自引率

7.50%

发文量

1327

审稿时长

2 months

期刊介绍： The Journal of Alzheimer''s Disease (JAD) is an international multidisciplinary journal to facilitate progress in understanding the etiology, pathogenesis, epidemiology, genetics, behavior, treatment and psychology of Alzheimer''s disease. The journal publishes research reports, reviews, short communications, hypotheses, ethics reviews, book reviews, and letters-to-the-editor. The journal is dedicated to providing an open forum for original research that will expedite our fundamental understanding of Alzheimer''s disease.