Immunotherapy in chronic lymphocytic leukemia: advances and challenges.

IF 9.4 1区医学 Q1 HEMATOLOGY

Experimental Hematology & Oncology Pub Date : 2025-04-10 DOI:10.1186/s40164-025-00644-5

Pan Gao, Yang Zhang, Jun Ma, Ya Zhang

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Abstract

Chronic lymphocytic leukemia (CLL) is characterized as a clonal proliferation of mature B lymphocytes with distinct immunophenotypic traits, predominantly affecting the middle-aged and elderly population. This condition is marked by an accumulation of lymphocytes within the peripheral blood, bone marrow, spleen, and lymph nodes. The associated immune dysregulation predisposes CLL patients to a higher risk of secondary malignancies and infections, which significantly contribute to morbidity and mortality rates. The advent of immunotherapy has revolutionized the prognosis of CLL, advancing treatment modalities and offering substantial benefits to patient outcomes. This review endeavors to synthesize and scrutinize the efficacy, merits, and limitations of the current immunotherapeutic strategies for CLL. The aim is to inform the selection of optimal treatment regimens tailored to individual patient needs. Furthermore, the review juxtaposes various therapeutic combinations to elucidate the comparative advantages of each approach, with the ultimate objective of enhancing patient prognosis and quality of life.

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慢性淋巴细胞白血病的免疫治疗：进展和挑战。

慢性淋巴细胞白血病（Chronic lymphocytic leukemia， CLL）的特点是成熟B淋巴细胞的克隆性增殖，具有独特的免疫表型特征，主要发生在中老年人群中。这种疾病的特点是外周血、骨髓、脾脏和淋巴结中淋巴细胞的积累。相关的免疫失调使CLL患者继发性恶性肿瘤和感染的风险更高，这大大增加了发病率和死亡率。免疫疗法的出现彻底改变了CLL的预后，推进了治疗方式，并为患者的预后提供了实质性的好处。这篇综述试图综合和仔细研究目前CLL免疫治疗策略的疗效、优点和局限性。其目的是告知选择适合个体患者需要的最佳治疗方案。此外，回顾并列各种治疗组合，以阐明每种方法的比较优势，最终目的是提高患者的预后和生活质量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Experimental Hematology & Oncology Medicine-Oncology

CiteScore

12.60

自引率

7.30%

发文量

审稿时长

6 weeks

期刊介绍： Experimental Hematology & Oncology is an open access journal that encompasses all aspects of hematology and oncology with an emphasis on preclinical, basic, patient-oriented and translational research. The journal acts as an international platform for sharing laboratory findings in these areas and makes a deliberate effort to publish clinical trials with 'negative' results and basic science studies with provocative findings. Experimental Hematology & Oncology publishes original work, hypothesis, commentaries and timely reviews. With open access and rapid turnaround time from submission to publication, the journal strives to be a hub for disseminating new knowledge and discussing controversial topics for both basic scientists and busy clinicians in the closely related fields of hematology and oncology.