Sharjeel Usmani, Anjali Jain, Khulood Al Riyami, Hajar Almarzouqi, Vipin Velangadi Jayakrishan, Subash Kheruka, Rashid Al Sukati
{"title":"Inflammatory Mimicry: Epididymo-orchitis Masquerading as Malignancy on [18F]-FDG PET/CT Imaging.","authors":"Sharjeel Usmani, Anjali Jain, Khulood Al Riyami, Hajar Almarzouqi, Vipin Velangadi Jayakrishan, Subash Kheruka, Rashid Al Sukati","doi":"10.4103/ijnm.ijnm_92_24","DOIUrl":null,"url":null,"abstract":"<p><p>False positive findings in <sup>18</sup>F-fluorodeoxyglucose positron emission tomography-computed tomography (<sup>18</sup>F-FDG PET/CT) scans can present challenges in the accurate diagnosis and staging of various conditions. We report a case of a 52-year-old male with known adenocarcinoma of the stomach who underwent total gastrectomy and chemotherapy and was referred for <sup>18</sup>F-FDG PET/CT to rule out recurrence. <sup>18</sup>F-FDG PET/CT showed a large FDG-avid lesion involving the entire right testicle mimicking testicular cancer or lymphoma. Further evaluation with ultrasonography revealed epididymo-orchitis, possibly of granulomatous etiology. Orchitis, an inflammatory condition of the testicles, can cause misleading results in <sup>18</sup>F-FDG PET/CT imaging for cancer surveillance. Imagers should cautiously interpret PET/CT findings, considering clinical context, patient history, and additional imaging modalities to distinguish true malignancies from false positives.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"39 6","pages":"466-468"},"PeriodicalIF":0.4000,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12020974/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Indian Journal of Nuclear Medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4103/ijnm.ijnm_92_24","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/3/20 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
引用次数: 0
Abstract
False positive findings in 18F-fluorodeoxyglucose positron emission tomography-computed tomography (18F-FDG PET/CT) scans can present challenges in the accurate diagnosis and staging of various conditions. We report a case of a 52-year-old male with known adenocarcinoma of the stomach who underwent total gastrectomy and chemotherapy and was referred for 18F-FDG PET/CT to rule out recurrence. 18F-FDG PET/CT showed a large FDG-avid lesion involving the entire right testicle mimicking testicular cancer or lymphoma. Further evaluation with ultrasonography revealed epididymo-orchitis, possibly of granulomatous etiology. Orchitis, an inflammatory condition of the testicles, can cause misleading results in 18F-FDG PET/CT imaging for cancer surveillance. Imagers should cautiously interpret PET/CT findings, considering clinical context, patient history, and additional imaging modalities to distinguish true malignancies from false positives.