Evaluation of the serum levels of endothelin-1 and lipid profile in chronic periodontitis patients, before and after periodontal therapy.

Abstract

Aim: To evaluate the serum level of endothelin-1 (ET-1) and lipid profile in chronic periodontitis patients before and after periodontal therapy.

Materials and methods: Sixty systemically healthy patients were divided into two groups, each with 30 patients. Group A with 30 healthy individuals and Group B with 30 chronic periodontitis patients. Group B was further divided into Group B1 and Group B2. Group B1 consisted of 15 patients with clinical attachment loss (CAL) of 1-2 mm treated by nonsurgical periodontal therapy. Group B2 of 15 patients with CAL of 3-4 mm, treated by periodontal flap surgery. Blood samples were collected before and 3 months following periodontal treatment to determine the serum level of ET-1 and lipid profile.

Results: There was a statistically significant difference in ET-1 and lipid profile levels before and after periodontal treatment in both Groups B1and B2. However, the difference was more significant in Group B2 than Group B1 (P < 0.001).

Conclusion: Serum ET-1 and lipid profile could be a potential biomarker for periodontal and cardiovascular diseases. Periodontal therapy could reduce the risk of cardiovascular disease by reducing ET-1 and lipid profile postoperatively.