Mutual Regulation of Cardiovascular and Hematopoietic Development.

IF 3.1 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Current Cardiology Reports Pub Date : 2025-04-22 DOI:10.1007/s11886-025-02236-5

Norika Liu, Haruko Nakano, Atsushi Nakano

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Abstract

Purpose of review: The cardiovascular and hematopoietic systems share molecular mechanisms and regulatory interactions across species. Endocardial hematopoiesis, a debated topic in mice, is actually an evolutionarily conserved process from Drosophila. This review explores the origins and significance of endocardial hematopoiesis, highlighting its role in cardiac development and macrophage formation.

Recent findings: Despite extensive lineage-tracing and transcriptome studies, it remained unclear until single-cell RNA sequencing (scRNA-seq) identified that endocardial cells possess an intrinsic hematopoietic program independent of known hematopoietic organs. These endocardial-derived macrophages contribute uniquely to cardiac morphogenesis, supporting valve maturation and tissue remodeling. Endocardial hematopoiesis is an evolutionarily conserved phenomenon that is essential for developmental process. The heterogeneity of tissue-resident macrophages and their specialized functions in cardiac development have been further unraveled by single-cell analysis. This review provides an evolutionary perspective on endocardial hematopoiesis and highlights its critical contributions of hematopoietic cells to heart formation and homeostasis.

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心血管和造血发育的相互调节。

综述目的：心血管和造血系统在不同物种间具有相同的分子机制和调控相互作用。心内膜造血，在小鼠中是一个有争议的话题，实际上是一个从果蝇进化保守的过程。本文综述了心内膜造血的起源和意义，重点介绍了心内膜造血在心脏发育和巨噬细胞形成中的作用。最近的发现：尽管进行了广泛的谱系追踪和转录组研究，但直到单细胞RNA测序（scRNA-seq）发现心内膜细胞具有独立于已知造血器官的内在造血程序之前，它仍然不清楚。这些心内膜来源的巨噬细胞在心脏形态发生、支持瓣膜成熟和组织重塑方面发挥着独特的作用。心内膜造血是一种进化保守的现象，对发育过程至关重要。组织巨噬细胞的异质性及其在心脏发育中的特殊功能已被单细胞分析进一步揭示。本文综述了心内膜造血的进化观点，并强调了造血细胞对心脏形成和稳态的重要贡献。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Cardiology Reports CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

6.20

自引率

2.70%

发文量

209

期刊介绍： The aim of this journal is to provide timely perspectives from experts on current advances in cardiovascular medicine. We also seek to provide reviews that highlight the most important recently published papers selected from the wealth of available cardiovascular literature. We accomplish this aim by appointing key authorities in major subject areas across the discipline. Section editors select topics to be reviewed by leading experts who emphasize recent developments and highlight important papers published over the past year. An Editorial Board of internationally diverse members suggests topics of special interest to their country/region and ensures that topics are current and include emerging research. We also provide commentaries from well-known figures in the field.