A One-Pot Synthesis of Substituted Pyrrolo[2,1-a]isoquinolines via an Oxidation/Annulation Sequence of 2-(3,4-Dihydroisoquinolin-2(1H)-yl)malononitriles.

IF 3.3 2区化学 Q1 CHEMISTRY, ORGANIC

Journal of Organic Chemistry Pub Date : 2025-05-15 DOI:10.1021/acs.joc.5c00639

Bang-Hong Zhang,Kai-Long Hou,Run-Ze Li,Fang-Fang Qiu,Ge-Ge Liu,Zi-Qin Wei,Wen Bao,Ye Zhang,Dao-Yong Zhu,Shao-Hua Wang

引用次数: 0

Abstract

A highly effective oxidation/annulation reaction between 2-isocyanoacetates and 2-(3,4-dihydroisoquinolin-2(1H)-yl)malononitriles has been successfully developed to give substituted pyrrolo[2,1-a]isoquinoline derivatives with moderate to good yields in a one-pot manner.

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2-（3,4-二氢异喹啉-2(1H)-基）丙二腈的氧化/环化序列一锅法合成取代吡咯[2,1- A]异喹啉

在2-异氰乙酸酯和2-（3,4-二氢异喹啉-2(1H)-酰基）丙二腈之间成功地建立了一种高效的氧化/环化反应，在一锅法下得到了收率中等至较高的取代吡咯[2,1- A]异喹啉衍生物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Organic Chemistry 化学-有机化学

CiteScore

6.20

自引率

11.10%

发文量

1467

审稿时长

2 months

期刊介绍： Journal of Organic Chemistry welcomes original contributions of fundamental research in all branches of the theory and practice of organic chemistry. In selecting manuscripts for publication, the editors place emphasis on the quality and novelty of the work, as well as the breadth of interest to the organic chemistry community.