Depemokimab in chronic rhinosinusitis with nasal polyps: A turning point or a missed opportunity?

IF 12.8 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Med Pub Date : 2025-05-09 DOI:10.1016/j.medj.2025.100674

Enrico Heffler, Giovanni Paoletti

引用次数: 0

Abstract

The ANCHOR-1 and ANCHOR-2 trials of the long-acting anti-interleukin (IL)-5 monoclonal antibody depemokibab in chronic rhinosinusitis with nasal polyposis demonstrated the safety and statistical efficacy of the drug compared to placebo.¹ However, its clinical benefits appear limited compared to other biologic therapies. The reduced dosing interval may improve adherence, but further research is needed to identify the most responsive patients.

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去替莫单抗治疗慢性鼻窦炎伴鼻息肉：转折点还是错失良机？

长效抗白细胞介素(IL)-5单克隆抗体depemokibab治疗慢性鼻窦炎伴鼻息肉的ANCHOR-1和ANCHOR-2试验表明，与安慰剂相比，该药具有安全性和统计学疗效然而，与其他生物疗法相比，其临床益处似乎有限。缩短给药间隔可能会提高依从性，但需要进一步的研究来确定最敏感的患者。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Med MEDICINE, RESEARCH & EXPERIMENTAL-

CiteScore

17.70

自引率

0.60%

发文量

102

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