Investigations on the dysregulated genes in high-fat-fed mice infected with Prevotella intermedia and their possible role in the development of hepatocellular carcinoma.

Abstract

Introduction: Hepatocellular carcinoma (HCC) is a leading global cancer, often linked to various factors, including viral infections and metabolic disorders. Recent studies suggest that microbial infections, particularly from oral pathogens like Prevotellaintermedia (Pi), may elevate the progression of HCC through dysbiosis and chronic inflammation.