Morphometry of the Human Ventral Germinal Matrix during Fetal Development.

IF 0.9 4区 医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL
A E Proshchina, E O Grushetskaya, A S Kharlamova, O S Godovalova, Yu S Krivova, S V Saveliev
{"title":"Morphometry of the Human Ventral Germinal Matrix during Fetal Development.","authors":"A E Proshchina, E O Grushetskaya, A S Kharlamova, O S Godovalova, Yu S Krivova, S V Saveliev","doi":"10.1007/s10517-025-06396-w","DOIUrl":null,"url":null,"abstract":"<p><p>The most important transient structures in human brain are the lateral ventricle eminences, or ganglionic eminences (eminentia ventricularis lateralis), the ventral part of germinal matrix. We performed quantitative analysis of the lateral ventricle eminences to clarify the spatial and temporal dynamic of the human prenatal brain development. Serial brain sections from 9 human fetuses at gestational weeks 12-30 were examined using a morphometric method. The volume of ganglionic eminences increased during the first and early second trimesters, reached maximum at weeks 20-21, and then gradual involution of the ventral germinal matrix was observed. The obtained data are comparable with the results from noninvasive imaging techniques, but have a higher resolution.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":"178 5","pages":"675-680"},"PeriodicalIF":0.9000,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bulletin of Experimental Biology and Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s10517-025-06396-w","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/4/29 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}
引用次数: 0

Abstract

The most important transient structures in human brain are the lateral ventricle eminences, or ganglionic eminences (eminentia ventricularis lateralis), the ventral part of germinal matrix. We performed quantitative analysis of the lateral ventricle eminences to clarify the spatial and temporal dynamic of the human prenatal brain development. Serial brain sections from 9 human fetuses at gestational weeks 12-30 were examined using a morphometric method. The volume of ganglionic eminences increased during the first and early second trimesters, reached maximum at weeks 20-21, and then gradual involution of the ventral germinal matrix was observed. The obtained data are comparable with the results from noninvasive imaging techniques, but have a higher resolution.

胎儿发育过程中人腹侧生发基质的形态测定。
人脑中最重要的瞬时结构是侧脑室突起或神经节突起(侧脑室突起),它是生发基质的腹侧部分。我们对侧脑室嵴进行了定量分析,以阐明人类产前大脑发育的时空动态。采用形态计量学方法对9例妊娠12-30周的人胎儿进行了连续脑切片检查。在妊娠早期和中期早期,神经节突起的体积增加,在第20-21周达到最大值,然后观察到腹侧生发基质逐渐退化。所获得的数据与无创成像技术的结果相当,但具有更高的分辨率。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Bulletin of Experimental Biology and Medicine
Bulletin of Experimental Biology and Medicine 医学-医学:研究与实验
CiteScore
1.50
自引率
14.30%
发文量
265
审稿时长
2 months
期刊介绍: Bulletin of Experimental Biology and Medicine presents original peer reviewed research papers and brief reports on priority new research results in physiology, biochemistry, biophysics, pharmacology, immunology, microbiology, genetics, oncology, etc. Novel trends in science are covered in new sections of the journal - Biogerontology and Human Ecology - that first appeared in 2005. World scientific interest in stem cells prompted inclusion into Bulletin of Experimental Biology and Medicine a quarterly scientific journal Cell Technologies in Biology and Medicine (a new Russian Academy of Medical Sciences publication since 2005). It publishes only original papers from the leading research institutions on molecular biology of stem and progenitor cells, stem cell as the basis of gene therapy, molecular language of cell-to-cell communication, cytokines, chemokines, growth and other factors, pilot projects on clinical use of stem and progenitor cells. The Russian Volume Year is published in English from April.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信