Proteasome: An antibiotic arsenal in anti-bacterial innate immunity

IF 14.5 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular Cell Pub Date : 2025-05-15 DOI:10.1016/j.molcel.2025.04.025

Yi Zheng, Chengjiang Gao

引用次数: 0

Abstract

The function of the proteasome besides degrading protein remains enigmatic. Goldberg et al. demonstrate that proteasomes can process proteins into antimicrobial peptides (AMPs) to ward off bacterial infection,¹ revealing a new function of proteasomes in innate immunity.

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蛋白酶体：抗细菌先天免疫中的一个抗生素库

蛋白酶体除降解蛋白质外，其功能仍是一个谜。Goldberg等人证明蛋白酶体可以将蛋白质加工成抗菌肽（AMPs）以抵御细菌感染，1揭示了蛋白酶体在先天免疫中的新功能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Cell 生物-生化与分子生物学

CiteScore

26.00

自引率

3.80%

发文量

389

审稿时长

1 months

期刊介绍： Molecular Cell is a companion to Cell, the leading journal of biology and the highest-impact journal in the world. Launched in December 1997 and published monthly. Molecular Cell is dedicated to publishing cutting-edge research in molecular biology, focusing on fundamental cellular processes. The journal encompasses a wide range of topics, including DNA replication, recombination, and repair; Chromatin biology and genome organization; Transcription; RNA processing and decay; Non-coding RNA function; Translation; Protein folding, modification, and quality control; Signal transduction pathways; Cell cycle and checkpoints; Cell death; Autophagy; Metabolism.