The effect of the PKR inhibitor, 2-aminopurine, on the replication of influenza A virus, and segment 8 mRNA splicing.

IF 1.7 4区生物学 Q3 BIOLOGY

Open Life Sciences Pub Date : 2025-04-28 eCollection Date: 2025-01-01 DOI:10.1515/biol-2025-1098

Dagny Lorent, Rafal Nowak, Monika Gazecka, Pawel Zmora, Elzbieta Lenartowicz Onyekaa

引用次数: 0

Abstract

Influenza A virus (IAV) is a negative-sense, single-stranded RNA virus, whose genome consists of eight segments encoding multiple structural and non-structural proteins essential for viral replication and host immune evasion. Among these, segment 8 encodes two primary non-structural proteins NS1, crucial for host immune suppression and virulence and NS2, involved in vRNP export - and their expression is regulated by splicing. Further studies are required to elucidate the role of PKR in IAV mRNA splicing regulation.

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PKR抑制剂2-氨基嘌呤对甲型流感病毒复制和8段mRNA剪接的影响

甲型流感病毒（IAV）是一种负义单链RNA病毒，其基因组由8个片段组成，编码病毒复制和宿主免疫逃避所必需的多种结构和非结构蛋白。其中，第8段编码两个主要非结构蛋白NS1和NS2，前者对宿主免疫抑制和毒力至关重要，后者参与vRNP输出，其表达受剪接调节。需要进一步的研究来阐明PKR在IAV mRNA剪接调控中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Open Life Sciences BIOLOGY-

CiteScore

2.50

自引率

4.50%

发文量

131

审稿时长

43 weeks

期刊介绍： Open Life Sciences (previously Central European Journal of Biology) is a fast growing peer-reviewed journal, devoted to scholarly research in all areas of life sciences, such as molecular biology, plant science, biotechnology, cell biology, biochemistry, biophysics, microbiology and virology, ecology, differentiation and development, genetics and many others. Open Life Sciences assures top quality of published data through critical peer review and editorial involvement throughout the whole publication process. Thanks to the Open Access model of publishing, it also offers unrestricted access to published articles for all users.