Liver stiffness and serum galectin 3 level significantly increases in patients with prediabetes: a fibroscan study.

IF 2.3 3区生物学 Q2 MULTIDISCIPLINARY SCIENCES

PeerJ Pub Date : 2025-04-23 eCollection Date: 2025-01-01 DOI:10.7717/peerj.19377

Huseyin Ali Ozturk, Hilmi Erdem Sumbul

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引用次数: 0

Abstract

Aim: Diabetes mellitus (DM) is associated with the development and progression of metabolic dysfunction-associated steatotic liver disease (MASLD). In our study, we aimed to evaluate the relationship between liver stiffness (LS) and galectin-3 levels in patients diagnosed with prediabetes.

Methods: A total of 120 participants were included in this prospective and cross-sectional study, comprising 40 patients with prediabetes, 40 patients with type 2 DM and 40 individuals with normal glucose metabolism. Human galectin-3 levels were measured using Enzyme-Linked Immunosorbent Assay (ELISA) with Human Galectin-3 kits. LS measurements were performed using the FibroScan® Mini 430 device (Echosens, France).

Results: In our study, we found that Fib-4 index, LS and galectin-3 levels were increased in patients with prediabetes. Another significant finding was that hemoglobin A1c (HbA1c) and galectin-3 levels were higher in patients with LS value ≥8 kPa and both HbA1c and galectin-3 levels were independently associated with LS.

Conclusion: Considering the increased prevalence of MASLD in prediabetes, we recommend early assessment of LS and measurement of galectin-3 levels in these patients.

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一项纤维扫描研究表明，糖尿病前期患者肝僵硬度和血清凝集素3水平显著升高。

目的：糖尿病（DM）与代谢功能障碍相关的脂肪变性肝病（MASLD）的发生和进展相关。在我们的研究中，我们旨在评估诊断为前驱糖尿病患者的肝脏僵硬（LS）和半凝集素-3水平之间的关系。方法：本前瞻性横断面研究共纳入120名参与者，包括40名糖尿病前期患者、40名2型糖尿病患者和40名糖代谢正常的患者。采用酶联免疫吸附法（ELISA）测定人半乳糖凝集素-3水平。LS测量使用FibroScan®Mini 430设备（Echosens，法国）进行。结果：在我们的研究中，我们发现前驱糖尿病患者的Fib-4指数、LS和半乳糖凝集素-3水平升高。另一个重要发现是，LS值≥8 kPa的患者血红蛋白A1c （HbA1c）和半乳糖凝集素-3水平较高，HbA1c和半乳糖凝集素-3水平与LS独立相关。结论：考虑到糖尿病前期MASLD患病率的增加，我们建议这些患者早期评估LS并测量半乳糖凝集素-3水平。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

PeerJ MULTIDISCIPLINARY SCIENCES-

CiteScore

4.70

自引率

3.70%

发文量

1665

审稿时长

10 weeks

期刊介绍： PeerJ is an open access peer-reviewed scientific journal covering research in the biological and medical sciences. At PeerJ, authors take out a lifetime publication plan (for as little as $99) which allows them to publish articles in the journal for free, forever. PeerJ has 5 Nobel Prize Winners on the Board; they have won several industry and media awards; and they are widely recognized as being one of the most interesting recent developments in academic publishing.