Interferon α2b Selectively Modulates Ionotropic AMPA, but not NMDA Receptors of the Glutamatergic Synapse of the Vestibular Apparatus.

IF 0.9 4区医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL

Bulletin of Experimental Biology and Medicine Pub Date : 2025-03-01 Epub Date: 2025-04-29 DOI:10.1007/s10517-025-06382-2

I V Ryzhova, E A Vershinina, T V Tobias

引用次数: 0

Abstract

Interferon (IFN) used in the treatment of severe viral infections and cancer can lead to acute hearing loss and balance problems. The effect of type I interferon IFNα2b on the function of the afferent glutamatergic synapse of the vestibular epithelium was studied in vitro using electrophysiological method and perfusion of the synaptic area with solutions containing glutamate (GLU) and ionotropic glutamate receptor agonists (AMPA, NMDA). IFNα2b selectively activates AMPA, but not NMDA receptors, and modulates the afferent flow from the sensory epithelium to CNS. The delayed activation of AMPA receptors is one of the mechanisms of the neuromodulatory effect of IFNα2b on glutamatergic synaptic transmission in the vestibular apparatus.

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干扰素α2b选择性调节前庭器官谷氨酸能突触的嗜离子性AMPA，而非NMDA受体。

干扰素（IFN）用于治疗严重的病毒感染和癌症，可导致急性听力丧失和平衡问题。采用体外电生理方法，用谷氨酸（GLU）和嗜离子型谷氨酸受体激动剂（AMPA、NMDA）溶液灌注突触区，研究I型干扰素IFNα2b对前庭上皮传入谷氨酸能突触功能的影响。IFNα2b选择性激活AMPA，而非NMDA受体，并调节从感觉上皮到中枢神经系统的传入流。AMPA受体的延迟激活是IFNα2b对前庭神经系统谷氨酸能突触传递的神经调节作用机制之一。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bulletin of Experimental Biology and Medicine 医学-医学：研究与实验

CiteScore

1.50

自引率

14.30%

发文量

265

审稿时长

2 months

期刊介绍： Bulletin of Experimental Biology and Medicine presents original peer reviewed research papers and brief reports on priority new research results in physiology, biochemistry, biophysics, pharmacology, immunology, microbiology, genetics, oncology, etc. Novel trends in science are covered in new sections of the journal - Biogerontology and Human Ecology - that first appeared in 2005. World scientific interest in stem cells prompted inclusion into Bulletin of Experimental Biology and Medicine a quarterly scientific journal Cell Technologies in Biology and Medicine (a new Russian Academy of Medical Sciences publication since 2005). It publishes only original papers from the leading research institutions on molecular biology of stem and progenitor cells, stem cell as the basis of gene therapy, molecular language of cell-to-cell communication, cytokines, chemokines, growth and other factors, pilot projects on clinical use of stem and progenitor cells. The Russian Volume Year is published in English from April.