Miao Yu, Xiaorui Wang, Lei Jia, Jingwan Han, Hanping Li, Xiaolin Wang, Bohan Zhang, Jingyun Li, Yongjian Liu, Hongling Wen, Lin Li
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引用次数: 0
Abstract
Since HIV-1 is a retrovirus with a high mutation rate and recombination rate, the virus contains a variety of genotypes and recombinants. The men who have sex with men (MSM) population in Beijing has become the main group of HIV transmission, and the co-transmission of multiple HIV-1 subtypes in the same high-risk group has led to the continuous generation of recombinants between various subtypes. In this study, two unique recombinant forms were identified in the samples from Beijing, and the full-length sequences were amplified and sequenced for analysis. Through the construction of phylogenetic trees and recombination breakpoint analysis, the two recombinants were identified as second-generation recombinants composed of CRF01_AE and CRF07_BC. The emergence of more complex recombinant strains poses new challenges to HIV prevention, and it is necessary to focus on monitoring the epidemic in the MSM population.
期刊介绍：
AIDS Research and Human Retroviruses was the very first AIDS publication in the field over 30 years ago, and today it is still the critical resource advancing research in retroviruses, including AIDS. The Journal provides the broadest coverage from molecular biology to clinical studies and outcomes research, focusing on developments in prevention science, novel therapeutics, and immune-restorative approaches. Cutting-edge papers on the latest progress and research advances through clinical trials and examination of targeted antiretroviral agents lead to improvements in translational medicine for optimal treatment outcomes.
AIDS Research and Human Retroviruses coverage includes:
HIV cure research
HIV prevention science
- Vaccine research
- Systemic and Topical PreP
Molecular and cell biology of HIV and SIV
Developments in HIV pathogenesis and comorbidities
Molecular biology, immunology, and epidemiology of HTLV
Pharmacology of HIV therapy
Social and behavioral science
Rapid publication of emerging sequence information.
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