The Parameters of Long-Term Humoral Immunity Induced by a Single Injection of the Sputnik Light Vaccine Among Noninfected Volunteers and Those Infected with SARS-CoV-2.

IF 2 4区 生物学 Q4 CELL BIOLOGY
F M Izhaeva, A I Tukhvatulin, A S Dzharullaeva, I V Dolzhikova, O V Zubkova, D V Shcheblyakov, N L Lubenets, E A Smolyarchuk, T G Zubkova, A S Erokhova, I M Cherenkova, K M Bukhtin, O Popova, N M Tukhvatulina, B S Naroditsky, D Y Logunov, A L Gintsburg
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引用次数: 0

Abstract

Although the immunogenicity of clinically approved COVID-19 vaccines remains under intensive investigation, little is still known about the parameters of long-term immune responses. In this paper, we present for the first time the parameters of humoral immunity studied in the phase 1-2 open-label clinical trial of the Sputnik Light vaccine, with a special focus on late follow-up time points (90 and 180 days). For the most accurate assessment of the parameters of humoral post-vaccination immunity (titer and avidity index of antigen-specific antibodies against the RBD domain of SARS-CoV-2), we conducted an additional analysis that allowed us to triage volunteers with immunity formed only in response to vaccination, as well as those with hybrid immunity (infected with SARS-CoV-2 before and after vaccination). The findings indicate that single-shot vaccination with the Sputnik Light vaccine induces a durable (seroconversion 73% on day 180) and mature humoral immunity. Natural immunization as a result of the SARS-CoV-2 infection leads to significant changes in the studied parameters of post-vaccination immunity.

非感染志愿者和SARS-CoV-2感染者单次注射Sputnik轻型疫苗长期体液免疫参数的研究
尽管临床批准的COVID-19疫苗的免疫原性仍在深入研究中,但对长期免疫反应的参数仍知之甚少。在本文中,我们首次介绍了Sputnik Light疫苗1-2期开放标签临床试验中研究的体液免疫参数,特别关注后期随访时间点(90天和180天)。为了最准确地评估疫苗接种后体液免疫的参数(针对SARS-CoV-2 RBD结构域的抗原特异性抗体的滴度和亲和力指数),我们进行了额外的分析,使我们能够对仅因疫苗接种而形成免疫的志愿者以及混合免疫的志愿者(接种前后感染了SARS-CoV-2)进行分类。结果表明,单次接种Sputnik Light疫苗可诱导持久(180天血清转化率为73%)和成熟的体液免疫。SARS-CoV-2感染后的自然免疫导致疫苗接种后免疫参数的显著变化。
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来源期刊
Acta Naturae
Acta Naturae 农林科学-林学
CiteScore
3.50
自引率
5.00%
发文量
0
审稿时长
>12 weeks
期刊介绍: Acta Naturae is an international journal on life sciences based in Moscow, Russia. Our goal is to present scientific work and discovery in molecular biology, biochemistry, biomedical disciplines and biotechnology. These fields represent the most important priorities for the research and engineering development both in Russia and worldwide. Acta Naturae is also a periodical for those who are curious in various aspects of biotechnological business, innovations in pharmaceutical areas, intellectual property protection and social consequences of scientific progress. The journal publishes analytical industrial surveys focused on the development of different spheres of modern life science and technology. Being a radically new and totally unique journal in Russia, Acta Naturae is useful to both representatives of fundamental research and experts in applied sciences.
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