Upadacitinib Monotherapy After Tofacitinib Failure Was Successful for Induction But Not Maintenance of Remission in Medically Refractory Ulcerative Colitis.

IF 0.6 Q4 GASTROENTEROLOGY & HEPATOLOGY

ACG Case Reports Journal Pub Date : 2025-04-16 eCollection Date: 2025-04-01 DOI:10.14309/crj.0000000000001673

Mark Chatto, Vipul Jairath

引用次数: 0

Abstract

This small case series represents real-world experience of the efficacy of upadacitinib after prior tofacitinib failure in medically refractory ulcerative colitis and challenges current observations that upadacitinib is effective after tofacitinib exposure. Although all patients had a clinical or partial response after upadacitinib induction, 4/4 (100%) patients relapsed or required rescue therapy during maintenance, in contrast to previous publications.

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托法替尼失败后Upadacitinib单药治疗成功诱导但不能维持药物难治性溃疡性结肠炎的缓解。

这个小病例系列代表了在先前托法替尼治疗难治性溃疡性结肠炎失败后upadacitinib疗效的真实世界经验，并挑战了目前关于托法替尼暴露后upadacitinib有效的观察结果。虽然所有患者在upadacitinib诱导后均有临床或部分缓解，但4/4（100%）患者在维持期间复发或需要抢救治疗，这与之前的报道相反。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACG Case Reports Journal GASTROENTEROLOGY & HEPATOLOGY-

自引率

14.30%

发文量

170

审稿时长

12 weeks

期刊介绍： ACG Case Reports Journal is a peer-reviewed, open-access publication that provides GI and hepatology fellows, private practice clinicians, and other healthcare providers an opportunity to share interesting case reports with their peers and with leaders in the field. ACG Case Reports Journal publishes case reports, images, videos and letters to the editor in all topics of gastroenterology and hepatology, including: Biliary Colon Endoscopy Esophagus Functional Bowel Disorders Inflammatory Bowel Disease Liver Nutrition and Obesity Pancreas Pathology Pediatric Small Bowel Stomach.