A Rare Presentation of a Devastating Disease: Hepatosplenic T-Cell Lymphoma in Crohn's Disease Without Thiopurine Exposure.

IF 0.5 Q4 GASTROENTEROLOGY & HEPATOLOGY

ACG Case Reports Journal Pub Date : 2025-05-08 eCollection Date: 2025-05-01 DOI:10.14309/crj.0000000000001695

Michael Chang, Michael Frohlinger, Nathan Williams, Lauren George

引用次数: 0

Abstract

Hepatosplenic T-cell lymphoma (HSTCL) is a rare, aggressive malignancy that has been associated with thiopurines during the treatment of inflammatory bowel disease (IBD). We present a case of a 26-year-old man with Crohn's disease on infliximab without prior thiopurine exposure who developed HSTCL. His diagnosis was confirmed through flow cytometry, fluorescence in situ hybridization, and bone marrow biopsy. This is the sixth case of HSTCL in patients with IBD without prior thiopurine exposure and highlights the need for a comprehensive risk-benefit discussion with patients on the various treatment modalities for IBD.

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一种罕见的毁灭性疾病的表现：没有硫嘌呤暴露的克罗恩病肝脾t细胞淋巴瘤。

肝脾t细胞淋巴瘤（HSTCL）是一种罕见的侵袭性恶性肿瘤，在治疗炎症性肠病（IBD）期间与硫嘌呤相关。我们提出一个26岁的男子克罗恩病的英夫利昔单抗没有事先暴露于硫嘌呤谁发展HSTCL。通过流式细胞术、荧光原位杂交和骨髓活检证实了他的诊断。这是第6例没有硫嘌呤暴露的IBD患者HSTCL，强调了与IBD患者就各种治疗方式进行全面的风险-收益讨论的必要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACG Case Reports Journal GASTROENTEROLOGY & HEPATOLOGY-

自引率

14.30%

发文量

170

审稿时长

12 weeks

期刊介绍： ACG Case Reports Journal is a peer-reviewed, open-access publication that provides GI and hepatology fellows, private practice clinicians, and other healthcare providers an opportunity to share interesting case reports with their peers and with leaders in the field. ACG Case Reports Journal publishes case reports, images, videos and letters to the editor in all topics of gastroenterology and hepatology, including: Biliary Colon Endoscopy Esophagus Functional Bowel Disorders Inflammatory Bowel Disease Liver Nutrition and Obesity Pancreas Pathology Pediatric Small Bowel Stomach.