{"title":"Tagatose 1,6-bisphosphate aldolases, the unloved DHAP-aldolases.","authors":"Christine Guérard-Hélaine, Léo Paulat, Marielle Lemaire, Virgil Hélaine","doi":"10.1002/cbic.202500285","DOIUrl":null,"url":null,"abstract":"<p><p>Tagatose-1,6-bisphosphate aldolases (TagA) have been understudied. The limited publications on the subject report a poor stereoselectivity, which quickly led to their classification among the less interesting aldolases. This conclusion, which appeared inadequate, discouraged further investigation by other researchers. The objective here is to re-examine all these studies in detail to finally uncover inconsistencies and unexplained observations regarding the behaviour of these enzymes. Ultimately, there is a significant lack of research that could deepen our understanding of TagA, which would likely reveal its potential to be as valuable as its counterparts: fructose-1,6-bisphosphate, rhamnulose-1-phosphate, and fuculose-1-phosphate aldolases.</p>","PeriodicalId":140,"journal":{"name":"ChemBioChem","volume":" ","pages":"e202500285"},"PeriodicalIF":2.6000,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ChemBioChem","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1002/cbic.202500285","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
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Abstract
Tagatose-1,6-bisphosphate aldolases (TagA) have been understudied. The limited publications on the subject report a poor stereoselectivity, which quickly led to their classification among the less interesting aldolases. This conclusion, which appeared inadequate, discouraged further investigation by other researchers. The objective here is to re-examine all these studies in detail to finally uncover inconsistencies and unexplained observations regarding the behaviour of these enzymes. Ultimately, there is a significant lack of research that could deepen our understanding of TagA, which would likely reveal its potential to be as valuable as its counterparts: fructose-1,6-bisphosphate, rhamnulose-1-phosphate, and fuculose-1-phosphate aldolases.
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ChemBioChem (Impact Factor 2018: 2.641) publishes important breakthroughs across all areas at the interface of chemistry and biology, including the fields of chemical biology, bioorganic chemistry, bioinorganic chemistry, synthetic biology, biocatalysis, bionanotechnology, and biomaterials. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies, and supported by the Asian Chemical Editorial Society (ACES).
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