Direct C–H fluorination/heteroarylation of oxindoles with quinoxalin-2(1H)-ones using Selectfluor†

IF 2.9 3区化学 Q1 CHEMISTRY, ORGANIC

Organic & Biomolecular Chemistry Pub Date : 2025-04-30 DOI:10.1039/D5OB00427F

Hui Qin, Guo-Liang Wei, Wen-Geng Xie, Xiao-Hong Mao, Fu-Wei Wang, Mei-Hua Bao, Xiao-Wei Zheng, Yi-Wen Zhang and Ping Huang

引用次数: 0

Abstract

Herein, we present an efficient and feasible strategy for direct C–H fluorination and heteroarylation of oxindoles on the C-3 position having a C(sp³)–H bond with quinoxalin-2(1H)-ones based on a radical coupling reaction via Selectfluor, a bifunctional reagent, as both the oxidant and fluorine source. This methodology provides a potential protocol to obtain 3-heteroaryl 3-fluorooxindoles in medium to excellent yields.

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用selectflut直接C-H氟化/氧吲哚与喹诺沙林-2(1H)- 1的异芳基化。

本研究通过双功能试剂Selectfluor作为氧化剂和氟源，对具有C(sp3)-H键的喹啉-2(1H)-化合物进行自由基偶联反应，提出了一种高效可行的C-3位氧吲哚进行直接C-H氟化和杂芳化的策略。该方法提供了一种以中等至优异收率获得3-杂芳基3-氟辛酮的潜在方案。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organic & Biomolecular Chemistry 化学-有机化学

CiteScore

5.50

自引率

9.40%

发文量

1056

审稿时长

1.3 months

期刊介绍： Organic & Biomolecular Chemistry is an international journal using integrated research in chemistry-organic chemistry. Founded in 2003 by the Royal Society of Chemistry, the journal is published in Semimonthly issues and has been indexed by SCIE, a leading international database. The journal focuses on the key research and cutting-edge progress in the field of chemistry-organic chemistry, publishes and reports the research results in this field in a timely manner, and is committed to becoming a window and platform for rapid academic exchanges among peers in this field. The journal's impact factor in 2023 is 2.9, and its CiteScore is 5.5.