Small brains but big challenges: white matter tractography in early life samples.

IF 2.7 3区医学 Q1 ANATOMY & MORPHOLOGY

Brain Structure & Function Pub Date : 2025-04-28 DOI:10.1007/s00429-025-02922-8

Jessica Dubois, Mareike Grotheer, Joseph Yuan-Mou Yang, Jacques-Donald Tournier, Christian Beaulieu, Catherine Lebel

引用次数: 0

Abstract

In the human brain, white matter development is a complex and long-lasting process involving intermingling micro- and macrostructural mechanisms, such as fiber growth, pruning and myelination. Did you know that all these neurodevelopmental changes strongly affect MRI signals, with consequences on tractography performances and reliability? This communication aims to elaborate on these aspects, highlighting the importance of tracking and studying the developing connections with dedicated approaches.

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大脑小但挑战大：早期生命样本的白质束状图。

在人脑中，白质发育是一个复杂而持久的过程，涉及微观和宏观结构机制，如纤维生长、修剪和髓鞘形成。你知道所有这些神经发育的变化会强烈地影响核磁共振成像信号，从而影响神经束造影的表现和可靠性吗？本通讯旨在详细阐述这些方面，强调用专用方法跟踪和研究发展中的联系的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Brain Structure & Function 医学-解剖学与形态学

CiteScore

6.00

自引率

6.50%

发文量

168

审稿时长

8 months

期刊介绍： Brain Structure & Function publishes research that provides insight into brain structure−function relationships. Studies published here integrate data spanning from molecular, cellular, developmental, and systems architecture to the neuroanatomy of behavior and cognitive functions. Manuscripts with focus on the spinal cord or the peripheral nervous system are not accepted for publication. Manuscripts with focus on diseases, animal models of diseases, or disease-related mechanisms are only considered for publication, if the findings provide novel insight into the organization and mechanisms of normal brain structure and function.