Chiral Brønsted acid-catalyzed intermolecular hydrophenoxylation of ynamides with biaryl phenols via sequential desymmetrization/kinetic resolution†

IF 2.9 3区化学 Q1 CHEMISTRY, ORGANIC

Organic & Biomolecular Chemistry Pub Date : 2025-05-07 DOI:10.1039/D5OB00503E

Yu Yu and Min Chen

引用次数: 0

Abstract

Herein we disclose the first catalytic asymmetric intermolecular hydrophenoxylation of ynamides with biaryl phenols under chiral Brønsted acid catalysis, providing axially chiral phenols. This enantioselective reaction proceeds through a sequential desymmetrizaiton/kinetic resolution process, which features mild reaction conditions and represents a rare paradigm of an organocatalytic asymmetric intermolecular reaction of ynamides.

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手性Brønsted酸催化双芳基苯酚与酰胺的分子间氢苯氧基化反应

在此，我们首次在手性Brønsted酸催化下，催化酰胺与联芳酚的不对称分子间氢苯氧基化，得到了轴向手性苯酚。该对映选择性反应通过连续的去对称/动力学分解过程进行，具有温和的反应条件，代表了罕见的有机催化不对称酰胺分子间反应的范例。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organic & Biomolecular Chemistry 化学-有机化学

CiteScore

5.50

自引率

9.40%

发文量

1056

审稿时长

1.3 months

期刊介绍： Organic & Biomolecular Chemistry is an international journal using integrated research in chemistry-organic chemistry. Founded in 2003 by the Royal Society of Chemistry, the journal is published in Semimonthly issues and has been indexed by SCIE, a leading international database. The journal focuses on the key research and cutting-edge progress in the field of chemistry-organic chemistry, publishes and reports the research results in this field in a timely manner, and is committed to becoming a window and platform for rapid academic exchanges among peers in this field. The journal's impact factor in 2023 is 2.9, and its CiteScore is 5.5.