Modifying the modifiers: ubiquitination of ADP-ribosylation in human cells.

IF 11.6 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Trends in Biochemical Sciences Pub Date : 2025-04-21 DOI:10.1016/j.tibs.2025.03.010

Karla L H Feijs-Žaja, Jonas Siefert, Roko Žaja

引用次数: 0

Abstract

Ubiquitination and ADP-ribosylation are protein post-translational modifications (PTMs) which influence diverse protein properties. In vitro work has indicated that ubiquitin can be ADP-ribosylated and vice versa, ADP-ribose ubiquitinated. An exciting new study by Bejan et al. now demonstrates that ubiquitination of ADP-ribosylated proteins, termed MARUbylation, occurs in human cells.

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修饰剂的修饰：人类细胞中adp -核糖基化的泛素化。

泛素化和adp核糖基化是影响蛋白质多种特性的蛋白质翻译后修饰（PTMs）。体外研究表明，泛素可以被adp核糖基化，反之亦然，adp核糖泛素化。Bejan等人的一项令人兴奋的新研究表明，adp核糖化蛋白的泛素化（称为marubyation）发生在人类细胞中。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in Biochemical Sciences 生物-生化与分子生物学

CiteScore

22.90

自引率

0.70%

发文量

148

审稿时长

6-12 weeks

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