Decoding the minute-by-minute GPCR interactome unveils hormone signaling gatekeepers

IF 7.2 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cell Chemical Biology Pub Date : 2025-05-15 DOI:10.1016/j.chembiol.2025.04.012

Wenqing Shui

引用次数: 0

Abstract

In this issue of Cell Chemical Biology, Shchepinova et al.¹ map the luteinizing hormone receptor (LHR) interactome with sub-minute precision. They identify novel regulators, such as RAP2B, which influences cAMP signaling and endosomal trafficking, enhancing our understanding of GPCR-mediated intracellular signaling and interactome dynamics.

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解码每分钟的GPCR相互作用组揭示激素信号的守门人

在这一期的《细胞化学生物学》中，Shchepinova等人1以亚分钟的精度绘制了黄体生成素受体（LHR）相互作用组。他们发现了新的调节因子，如RAP2B，它影响cAMP信号传导和内体运输，增强了我们对gpcr介导的细胞内信号传导和相互作用动力学的理解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell Chemical Biology Biochemistry, Genetics and Molecular Biology-Molecular Medicine

CiteScore

14.70

自引率

2.30%

发文量

143

期刊介绍： Cell Chemical Biology, a Cell Press journal established in 1994 as Chemistry & Biology, focuses on publishing crucial advances in chemical biology research with broad appeal to our diverse community, spanning basic scientists to clinicians. Pioneering investigations at the chemistry-biology interface, the journal fosters collaboration between these disciplines. We encourage submissions providing significant conceptual advancements of broad interest across chemical, biological, clinical, and related fields. Particularly sought are articles utilizing chemical tools to perturb, visualize, and measure biological systems, offering unique insights into molecular mechanisms, disease biology, and therapeutics.