Triterpenoids with inhibitory effects on lipid accumulation from Ganoderma lucidum

IF 2.5 3区医学 Q3 CHEMISTRY, MEDICINAL

Fitoterapia Pub Date : 2025-05-03 DOI:10.1016/j.fitote.2025.106585

Lu Chai , Xiao-Cui Liu , Zhou-Wei Wu , Yi Luo , Xin-Yu Tao , Xing-Rong Peng , Ming-Hua Qiu

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Abstract

Eight undescribed lanostane-type triterpenes (1–8) and twenty-seven known analogues (9–35) were isolated from the fruiting bodies of cultivated Ganoderma lucidum. The chemical structures of these compounds were elucidated using a combination of spectroscopic techniques. Ganosinenic acid D (1) and ganosinenic acid E (2) were identified as rare pentacyclic triterpenoids with an unusual four-membered carbon ring motif. The inhibitory effects of all compounds on lipid accumulation were evaluated in oleic acid (OA)-induced HepG2 cells. Among the tested compounds, ganolucidic acid G (7), lucidenic acid N (9), methyl lucidenate M (29) showed moderate inhibitory effects. Furthermore, lucidenic acid N inhibited lipid accumulation in a dose-dependent manner. The structure-activity relationship analysis revealed enhanced efficacy in side chain-degraded C₂₇ nor-triterpenoids compared to C₂₄ and C₃₀ analogs.

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三萜类化合物对灵芝脂质积累的抑制作用

从栽培灵芝子实体中分离得到8个未描述的毛甾烷型三萜（1-8）和27个已知的类似物（9-35）。这些化合物的化学结构用光谱技术的组合加以阐明。甘油三酯酸D(1)和甘油三酯酸E(2)被鉴定为罕见的五环三萜，具有罕见的四元碳环基序。在油酸（OA）诱导的HepG2细胞中评估了所有化合物对脂质积累的抑制作用。在所测化合物中，甘酸G(7)、lucidenacid N(9)、甲基lucidenate M（29）表现出中等的抑制作用。此外，lucidenacid N以剂量依赖的方式抑制脂质积累。构效关系分析显示，与C24和C30类似物相比，C27对侧链降解的非三萜类化合物的功效增强。

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来源期刊

Fitoterapia 医学-药学

CiteScore

5.80

自引率

2.90%

发文量

198

审稿时长

1.5 months

期刊介绍： Fitoterapia is a Journal dedicated to medicinal plants and to bioactive natural products of plant origin. It publishes original contributions in seven major areas: 1. Characterization of active ingredients of medicinal plants 2. Development of standardization method for bioactive plant extracts and natural products 3. Identification of bioactivity in plant extracts 4. Identification of targets and mechanism of activity of plant extracts 5. Production and genomic characterization of medicinal plants biomass 6. Chemistry and biochemistry of bioactive natural products of plant origin 7. Critical reviews of the historical, clinical and legal status of medicinal plants, and accounts on topical issues.