Balancing stealth and targeting to improve nanomedicine efficacy

IF 38.1 1区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Nature nanotechnology Pub Date : 2025-05-13 DOI:10.1038/s41565-025-01926-z

Yi Ju, Stephen John Kent

引用次数: 0

Abstract

Developing nanomedicines that avoid fast blood clearance while retaining targeting specificity in vivo is inherently challenging. Leveraging the individual biomolecular corona, optimizing the nature of targeting ligands and exploring alternative stealth formulations might be the key to engineering tailored nanomedicine approaches.

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平衡隐身与靶向，提高纳米药物疗效

开发避免快速血液清除同时保持体内靶向特异性的纳米药物本身就是一项挑战。利用单个生物分子电晕，优化靶向配体的性质，探索替代的隐形配方，可能是设计定制纳米医学方法的关键。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature nanotechnology 工程技术-材料科学：综合

CiteScore

59.70

自引率

0.80%

发文量

196

审稿时长

4-8 weeks

期刊介绍： Nature Nanotechnology is a prestigious journal that publishes high-quality papers in various areas of nanoscience and nanotechnology. The journal focuses on the design, characterization, and production of structures, devices, and systems that manipulate and control materials at atomic, molecular, and macromolecular scales. It encompasses both bottom-up and top-down approaches, as well as their combinations. Furthermore, Nature Nanotechnology fosters the exchange of ideas among researchers from diverse disciplines such as chemistry, physics, material science, biomedical research, engineering, and more. It promotes collaboration at the forefront of this multidisciplinary field. The journal covers a wide range of topics, from fundamental research in physics, chemistry, and biology, including computational work and simulations, to the development of innovative devices and technologies for various industrial sectors such as information technology, medicine, manufacturing, high-performance materials, energy, and environmental technologies. It includes coverage of organic, inorganic, and hybrid materials.