Pd-Catalyzed Photoinduced Interceptive Decarboxylative Allylation

IF 14.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Journal of the American Chemical Society Pub Date : 2025-05-12 DOI:10.1021/jacs.5c03044

Franz-Lucas Haut, Filip S. Meger, Tomás G. Santiago, Paula Fraňová, Daniel Kocsi, Joan V. Estornell, Marta Martínez-Belmonte, Jordi Benet-Buchholz, Ruben Martin

引用次数: 0

Abstract

Herein, we describe a photoinduced Pd-catalyzed interceptive decarboxylative allylation of allyl esters. Our protocol provides a new gateway to enable atom pair swaps or a series of contractions and elongations, thus offering unconventional disconnections and a modular yet broadly applicable tool for rapidly and reliably accessing sp³ architectures in drug discovery.

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pd催化的光诱导拦截脱羧烯丙基化

在这里，我们描述了光诱导的pd催化的烯丙基酯的拦截脱羧烯丙基化。我们的协议提供了一个新的网关来实现原子对交换或一系列收缩和延长，从而提供了非常规的断开和模块化但广泛适用的工具，用于快速可靠地访问药物发现中的sp3结构。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of the American Chemical Society 化学-化学综合

CiteScore

24.40

自引率

6.00%

发文量

2398

审稿时长

1.6 months

期刊介绍： The flagship journal of the American Chemical Society, known as the Journal of the American Chemical Society (JACS), has been a prestigious publication since its establishment in 1879. It holds a preeminent position in the field of chemistry and related interdisciplinary sciences. JACS is committed to disseminating cutting-edge research papers, covering a wide range of topics, and encompasses approximately 19,000 pages of Articles, Communications, and Perspectives annually. With a weekly publication frequency, JACS plays a vital role in advancing the field of chemistry by providing essential research.