Ubiquitin-SUMO tag-team wrestles acute promyelocytic leukemia.

IF 7.4 1区生物学 Q1 CELL BIOLOGY

Journal of Cell Biology Pub Date : 2025-05-09 DOI:10.1083/jcb.202504010

Alfred C O Vertegaal

引用次数: 0

Abstract

In this issue, Jaffray and colleagues (https://doi.org/10.1083/jcb.202407133) detail the molecular machinery required to degrade the oncogene PML in response to arsenic treatment. Different posttranslational modifiers team up: ubiquitin, SUMO1, and -2/3, linked by the SUMO-targeted ubiquitin ligases TOPORS and RNF4.

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泛素- sumo标签团队对抗急性早幼粒细胞白血病。

在本期杂志中，Jaffray及其同事（https://doi.org/10.1083/jcb.202407133）详细介绍了在砷处理下降解致癌基因PML所需的分子机制。不同的翻译后修饰因子组合在一起：泛素、SUMO1和-2/3，由sumo靶向的泛素连接酶TOPORS和RNF4连接。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Cell Biology 生物-细胞生物学

CiteScore

12.60

自引率

2.60%

发文量

213

审稿时长

1 months

期刊介绍： The Journal of Cell Biology (JCB) is a comprehensive journal dedicated to publishing original discoveries across all realms of cell biology. We invite papers presenting novel cellular or molecular advancements in various domains of basic cell biology, along with applied cell biology research in diverse systems such as immunology, neurobiology, metabolism, virology, developmental biology, and plant biology. We enthusiastically welcome submissions showcasing significant findings of interest to cell biologists, irrespective of the experimental approach.