Nano-formulation of phytochemicals to combat neurodegenerative diseases: Current and thorough strategies

Abstract

Nanoparticles have established potential in enhancing medication pharmacokinetics, biodegradability, and therapeutic efficacy, while decreasing adverse effects. By breaching the blood-brain barrier, they have the ability to modulate disturbed processes in neurodegenerative illnesses, including inflammatory processes, oxidative stress, apoptosis, and protein aggregation. Nanoparticle-based formulations targeting pathways contribute to mental and neurological illnesses, including Parkinson's disease, Amyotrophic Lateral Sclerosis, Alzheimer’s disease, Multiple sclerosis, and Huntington's syndrome. Various phytochemicals have shown potential for producing nano-formulations to treat Alzheimer's disease. Integrative medicine, combining Western and traditional medicine, has shown promising results in treating neurological problems. Various nano-formulations with bioactive phytochemicals have shown promising outcomes in treating various neuro-degenerative diseases through diverse ways. This review combines recent advancements in nanotechnology with neurodegenerative disease treatments, highlighting innovative approaches that focus on specific, lesser-explored phytochemicals or their novel combinations.