EXPRESSION OF CONCERN: Combined Pharmacological, Mutational and Cell Biology Approaches Indicate That p53-Dependent Caspase 3 Activation Triggered by Cellular Prion Is Dependent on Its Endocytosis

Abstract

EXPRESSION OF CONCERN: C. Sunyach and F. Checler, “Combined Pharmacological, Mutational and Cell Biology Approaches Indicate that p53-Dependent Caspase 3 Activation Triggered by Cellular Prion is Dependent on its Endocytosis,” Journal of Neurochemistry 92, no. 6 (2005): 1399–1407, https://doi.org/10.1111/j.1471-4159.2004.02989.x.

This Expression of Concern is for the above article, published online on 25 February 2005 in Wiley Online Library (wileyonlinelibrary.com), and has been issued by agreement between the journal Editor-in-Chief, Andrew Lawrence; the International Society for Neurochemistry; and John Wiley & Sons Ltd. A third party reported concerns that a portion of the tubulin control in Figure 2a had been manipulated. Additional investigation by the publisher found evidence that the tubulin bands in Figure 4b had been duplicated in Figure 5a. Author F. Checler responded to an inquiry by the publisher and stated that the concerns were unfounded but also stated that the original data were no longer available due to the time that has elapsed since publication and the departure of co-author C. Sunyach from research. The editors have determined that the evidence of image manipulation and duplication casts doubt on the results presented in the article, and that the veracity of the data presented cannot be confirmed due to the lack of original data. Therefore, the journal has decided to issue an Expression of Concern to inform and alert readers. Author F. Checler disagrees with the retraction. Author C. Sunyach could not be reached for comment regarding the Expression of Concern.