Novel Tricyclic Compounds as GSK3 Inhibitors

IF 3.5 3区医学 Q2 CHEMISTRY, MEDICINAL

ACS Medicinal Chemistry Letters Pub Date : 2025-04-04 DOI:10.1021/acsmedchemlett.5c0016210.1021/acsmedchemlett.5c00162

Yinlong Li, and , Steven H. Liang*,

引用次数: 0

Abstract

This patent highlight describes a series of novel tricyclic system-based compounds as glycogen synthase kinase 3 (GSK3) inhibitors. The inhibitory potency of these compounds against GSK3α and GSK3β has been evaluated, and their potential applications in treating GSK3-related diseases are explored.

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新型三环化合物作为GSK3抑制剂

本专利重点描述了一系列新的三环系化合物作为糖原合成酶激酶3 （GSK3）抑制剂。研究了这些化合物对GSK3α和GSK3β的抑制作用，并探讨了它们在治疗gsk3相关疾病中的潜在应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Medicinal Chemistry Letters CHEMISTRY, MEDICINAL-

CiteScore

7.30

自引率

2.40%

发文量

328

审稿时长

1 months

期刊介绍： ACS Medicinal Chemistry Letters is interested in receiving manuscripts that discuss various aspects of medicinal chemistry. The journal will publish studies that pertain to a broad range of subject matter, including compound design and optimization, biological evaluation, drug delivery, imaging agents, and pharmacology of both small and large bioactive molecules. Specific areas include but are not limited to: Identification, synthesis, and optimization of lead biologically active molecules and drugs (small molecules and biologics) Biological characterization of new molecular entities in the context of drug discovery Computational, cheminformatics, and structural studies for the identification or SAR analysis of bioactive molecules, ligands and their targets, etc. Novel and improved methodologies, including radiation biochemistry, with broad application to medicinal chemistry Discovery technologies for biologically active molecules from both synthetic and natural (plant and other) sources Pharmacokinetic/pharmacodynamic studies that address mechanisms underlying drug disposition and response Pharmacogenetic and pharmacogenomic studies used to enhance drug design and the translation of medicinal chemistry into the clinic Mechanistic drug metabolism and regulation of metabolic enzyme gene expression Chemistry patents relevant to the medicinal chemistry field.