Correction: SPOP‑mediated ubiquitination and degradation of PDK1 suppresses AKT kinase activity and oncogenic functions

Abstract

Correction: Mol Cancer 20, 100 (2021)

https://doi.org/10.1186/s12943-021-01397-5

Following publication of the original article [1], the authors identified the tubulin band of Figure 2C and 4M was duplicated used. They sincerely apologize for the inadvertent duplication during data arrangement. Here, they provide the original data to clarify that these tubulin bands were run on the same gel. However, when excising the bands, the wrong side was mistakenly used. The original raw data for all figures have been properly archived and are readily available for verification. Now they have corrected this error and provided the updated Figure 4. The error does not affect the conclusion. The updated Figure 4 is provided below.

Updated Fig. 4

Fig. 4

CK1/GSK3-mediated PDK1 phosphorylation promotes SPOP interaction with and ubiquitination of PDK1

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1. Jiang Q, Zheng N, Bu L, et al. SPOP-mediated ubiquitination and degradation of PDK1 suppresses AKT kinase activity and oncogenic functions. Mol Cancer. 2021;20:100. https://doi.org/10.1186/s12943-021-01397-5.

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Author notes

1. Qiwei Jiang, Nana Zheng and Lang Bu contributed equally to this work.

Authors and Affiliations

1. Institute of Precision Medicine, the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510275, Guangdong, China

   Qiwei Jiang, Lang Bu, Xiaomei Zhang, Yaqing Su, Lei Wang, Wei Xie & Jianping Guo

2. National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China

   Nana Zheng & Depei Wu

3. Key Laboratory of Organ Regeneration and Transplantation of the Ministry of Education, Institute of Immunology, The First Hospital, Jilin University, Jilin, Changchun, China

   Xiaoling Zhang & Xiangpeng Dai

4. National-Local Joint Engineering Laboratory of Animal Models for Human Diseases, Jilin, Changchun, China

   Xiaoling Zhang & Xiangpeng Dai

5. State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, Guangdong, China

   Yuanzhong Wu

6. Department of Urology, Shanghai Changhai Hospital, Shanghai, 200433, China

   Xiaomin Zhang, Shancheng Ren & Yasheng Zhu

7. Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA

   Wenyi Wei

Authors

1. Qiwei JiangView author publications

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2. Nana ZhengView author publications

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4. Xiaomei ZhangView author publications

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11. Xiangpeng DaiView author publications

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Corresponding authors

Correspondence to Wenyi Wei, Yasheng Zhu or Jianping Guo.

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Jiang, Q., Zheng, N., Bu, L. et al. Correction: SPOP‑mediated ubiquitination and degradation of PDK1 suppresses AKT kinase activity and oncogenic functions. Mol Cancer 24, 137 (2025). https://doi.org/10.1186/s12943-025-02347-1

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• Published: 07 May 2025

• DOI: https://doi.org/10.1186/s12943-025-02347-1

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