ANKRD26-related Thrombocytopenia 2 with a Baseline Increase in Blasts: Implications for Clinical Surveillance.

IF 21 1区医学 Q1 HEMATOLOGY

Blood Pub Date : 2025-05-07 DOI:10.1182/blood.2024027368

Lara Wahlster,Lucy A Godley,Jason X Cheng,Michael W Drazer,Christopher R Reilly,Geraldine S Pinkus,Jared H Rowe,Nina Weichert-Leahey,Robert Grant Rowe,Lev Gorfinkel,Karyn Jean Brundige,Franziska Wachter,Luana Miria Messa,Alan D Michelson,Alan B Cantor,Akiko Shimamura,Jacob R Bledsoe

引用次数: 0

Abstract

We report eight patients with ANKRD26-related thrombocytopenia-2 (ANKRD26-RT) with elevated bone marrow myeloblasts and dysmegakaryopoiesis, without somatic genetic abnormalities or progression to malignancy during long-term observation, findings which may constitute inherent ANKRD26-RT biology rather than progression to myeloid malignancy.

查看原文本刊更多论文

ankrd26相关的2型血小板减少症与原始细胞基线增加：临床监测的意义

我们报告了8例ankrd26相关血小板减少-2 （ANKRD26-RT）患者，伴有骨髓母细胞升高和巨核增生异常，在长期观察中没有体细胞遗传异常或恶性进展，这些发现可能构成固有的ANKRD26-RT生物学，而不是进展为髓系恶性肿瘤。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Blood 医学-血液学

CiteScore

23.60

自引率

3.90%

发文量

955

审稿时长

1 months

期刊介绍： Blood, the official journal of the American Society of Hematology, published online and in print, provides an international forum for the publication of original articles describing basic laboratory, translational, and clinical investigations in hematology. Primary research articles will be published under the following scientific categories: Clinical Trials and Observations; Gene Therapy; Hematopoiesis and Stem Cells; Immunobiology and Immunotherapy scope; Myeloid Neoplasia; Lymphoid Neoplasia; Phagocytes, Granulocytes and Myelopoiesis; Platelets and Thrombopoiesis; Red Cells, Iron and Erythropoiesis; Thrombosis and Hemostasis; Transfusion Medicine; Transplantation; and Vascular Biology. Papers can be listed under more than one category as appropriate.