A novel varicosavirus associated with Orychophragmus violaceus in China

IF 2.5 4区医学 Q3 VIROLOGY

Archives of Virology Pub Date : 2025-05-07 DOI:10.1007/s00705-025-06283-9

Yuanling Chen, Qian Li, Jiaping Yu, Yali Zhou, Shifang Fei, Jianxiang Wu, Shuai Fu

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引用次数: 0

Abstract

Plant rhabdoviruses have garnered considerable attention due to their broad host range and significant agricultural threats. Despite their prevalence in various ecosystems, rhabdoviruses in non-crop species, which often serve as reservoirs for novel viral strains, remain understudied. Here, a novel plant rhabdovirus, Orychophragmus violaceus varicosavirus (OVVV), was identified in the ornamental plant Orychophragmus violaceus and characterized by high-through sequencing. OVVV has a bisegmented genome, with RNA1 consisting of 6,795 nucleotides (nt) and RNA2 consisting of 5,895 nt. The L protein encoded by RNA1 shares 36.4–67.2% amino acid sequence identity with those of known varicosaviruses. The four proteins encoded by RNA2 share 19.5–53.4% amino acid identity with the corresponding proteins of known varicosaviruses. Sequence comparisons and phylogenetic analysis indicated that OVVV is a novel RNA virus representing a new species within the genus Varicosavirus. This discovery not only expands the known host range of varicosaviruses but also offers new insights into the molecular evolution of this group of viruses.

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中国一种与紫斑田鼠相关的新型静脉曲张病毒

植物横纹肌病毒由于其广泛的寄主范围和重大的农业威胁而引起了相当大的关注。尽管横纹肌病毒在各种生态系统中普遍存在，但在非作物物种中的横纹肌病毒（通常作为新病毒株的储存库）仍未得到充分研究。本文从观赏植物堇菜（Orychophragmus violaceus varicosavirus， OVVV）中鉴定出一种新的植物横纹病病毒，并通过高通量测序对其进行了鉴定。OVVV具有双片段的基因组，RNA1由6795个核苷酸组成，RNA2由5895个核苷酸组成。RNA1编码的L蛋白与已知的变异病毒具有364 - 67.2%的氨基酸序列同源性。RNA2编码的4种蛋白与已知变异病毒对应蛋白的氨基酸同源性为19.5 ~ 53.4%。序列比较和系统发育分析表明，OVVV是一种新的RNA病毒，代表了Varicosavirus属的一个新种。这一发现不仅扩大了已知的变异病毒宿主范围，而且为这类病毒的分子进化提供了新的见解。

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来源期刊

Archives of Virology 医学-病毒学

CiteScore

5.10

自引率

7.40%

发文量

324

审稿时长

4.5 months

期刊介绍： Archives of Virology publishes original contributions from all branches of research on viruses, virus-like agents, and virus infections of humans, animals, plants, insects, and bacteria. Coverage spans a broad spectrum of topics, from descriptions of newly discovered viruses, to studies of virus structure, composition, and genetics, to studies of virus interactions with host cells, organisms and populations. Studies employ molecular biologic, molecular genetics, and current immunologic and epidemiologic approaches. Contents include studies on the molecular pathogenesis, pathophysiology, and genetics of virus infections in individual hosts, and studies on the molecular epidemiology of virus infections in populations. Also included are studies involving applied research such as diagnostic technology development, monoclonal antibody panel development, vaccine development, and antiviral drug development.Archives of Virology wishes to publish obituaries of recently deceased well-known virologists and leading figures in virology.