The bone-muscle unit: from mechanical coupling to soluble factors-mediated signaling

IF 8.7 2区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular Aspects of Medicine Pub Date : 2025-05-07 DOI:10.1016/j.mam.2025.101367

Amir Mohammad Malvandi , Laura Gerosa , Giuseppe Banfi , Giovanni Lombardi

引用次数: 0

Abstract

Skeletal muscles (SKM) and bones form a morpho-functional unit, interconnected throughout life primarily through biomechanical coupling. This relationship serves as a key reciprocal stimulus, but they also interact via various hormones, such as sex steroids, growth hormone-insulin-like growth factor 1 (GH-IGF1) axis hormones, and adipokines like leptin and adiponectin. Additionally, myokines (released by muscles) and osteokines (released by bones) facilitate dense crosstalk, influencing each other's activity. Key myokines include interleukin (IL)-6, IL-7, IL-15, and myostatin, while osteocalcin (OC) and sclerostin are crucial bone-derived mediators affecting SKM cells. Moreover, miRNAs act as endocrine-like regulators, contributing to a complex network. This review covers the current understanding of bone-muscle crosstalk, which is essential for grasping the musculoskeletal apparatus's role in disease pathogenesis and may inform therapeutic development.

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骨骼肌单位：从机械偶联到可溶性因子介导的信号传导

骨骼肌（SKM）和骨骼形成形态功能单元，主要通过生物力学耦合在整个生命中相互联系。这种关系是一种关键的相互刺激，但它们也通过各种激素相互作用，如性类固醇、生长激素-胰岛素样生长因子1 （GH-IGF1）轴激素和脂肪因子，如瘦素和脂联素。此外，肌因子（由肌肉释放）和骨因子（由骨骼释放）促进密集的串扰，影响彼此的活动。关键的肌因子包括白细胞介素(IL)-6、IL-7、IL-15和肌肉生长抑制素，而骨钙素（OC）和硬化素是影响SKM细胞的关键骨源性介质。此外，mirna充当类似内分泌的调节器，有助于形成一个复杂的网络。本文综述了目前对骨骼肌串扰的理解，这对于掌握肌肉骨骼装置在疾病发病机制中的作用至关重要，并可能为治疗发展提供信息。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Aspects of Medicine 医学-生化与分子生物学

CiteScore

18.20

自引率

0.00%

发文量

审稿时长

55 days

期刊介绍： Molecular Aspects of Medicine is a review journal that serves as an official publication of the International Union of Biochemistry and Molecular Biology. It caters to physicians and biomedical scientists and aims to bridge the gap between these two fields. The journal encourages practicing clinical scientists to contribute by providing extended reviews on the molecular aspects of a specific medical field. These articles are written in a way that appeals to both doctors who may struggle with basic science and basic scientists who may have limited awareness of clinical practice issues. The journal covers a wide range of medical topics to showcase the molecular insights gained from basic science and highlight the challenging problems that medicine presents to the scientific community.