Differences in age-related distribution of CSF alpha-synuclein seeding and Alzheimer profiles between PD with and without GBA1 variants

IF 6.7 1区医学 Q1 NEUROSCIENCES

NPJ Parkinson's Disease Pub Date : 2025-05-05 DOI:10.1038/s41531-025-00978-1

Stefanie Lerche, Isabel Wurster, Benjamin Roeben, Milan Zimmermann, Marcello Rossi, Angela Mammana, Simone Baiardi, Ann‑Kathrin Hauser, Christian Deuschle, Claudia Schulte, Piero Parchi, Kathrin Brockmann

引用次数: 0

Abstract

We studied the age- and genetic-related prevalence of CSF alpha-Synuclein seeding and Alzheimer profiles in 188 samples from PD participants without GBA1 variants (PD_wildtype) and in 129 samples from PD participants with GBA1 variants (PD_GBA1). While Alzheimer profiles increased with age in PD_wildtype, it was sparse in PD_GBA1. Alpha-Synuclein profiles remained stable with age in both cohorts. In PD_wildtype, combined alpha-Synuclein/Alzheimer profiles were associated with earlier onset of cognitive impairment.

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伴有和不伴有GBA1变异的PD之间CSF α -突触核蛋白种子的年龄相关分布和阿尔茨海默病谱的差异

我们研究了188个没有GBA1变异（PDwildtype）的PD参与者样本和129个GBA1变异（PDGBA1）的PD参与者样本中脑脊液α -突触核蛋白种子和阿尔茨海默病的年龄和遗传相关患病率。在PDwildtype中，阿尔茨海默病谱随着年龄的增长而增加，而在PDGBA1中却很少。在两个队列中，α -突触核蛋白谱随年龄保持稳定。在PDwildtype中，联合α -突触核蛋白/阿尔茨海默病谱与认知障碍的早期发病有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

NPJ Parkinson's Disease Medicine-Neurology (clinical)

CiteScore

9.80

自引率

5.70%

发文量

156

审稿时长

11 weeks

期刊介绍： npj Parkinson's Disease is a comprehensive open access journal that covers a wide range of research areas related to Parkinson's disease. It publishes original studies in basic science, translational research, and clinical investigations. The journal is dedicated to advancing our understanding of Parkinson's disease by exploring various aspects such as anatomy, etiology, genetics, cellular and molecular physiology, neurophysiology, epidemiology, and therapeutic development. By providing free and immediate access to the scientific and Parkinson's disease community, npj Parkinson's Disease promotes collaboration and knowledge sharing among researchers and healthcare professionals.