{"title":"Slow awakening of the silent X chromosome in female primordial germ cells","authors":"Christine M. Disteche, Xinxian Deng","doi":"10.1038/s41594-025-01550-4","DOIUrl":null,"url":null,"abstract":"Programmed reactivation of the inactive X chromosome in mammals happens in female primordial germ cells (PGCs) to prepare for meiosis and the generation of haploid germ cells that contain a single active X chromosome. Two recent publications clarify the kinetics of X-chromosome reactivation (XCR) in vivo and implicate specific epigenetic modifications in the process.","PeriodicalId":18822,"journal":{"name":"Nature structural & molecular biology","volume":"73 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature structural & molecular biology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1038/s41594-025-01550-4","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Programmed reactivation of the inactive X chromosome in mammals happens in female primordial germ cells (PGCs) to prepare for meiosis and the generation of haploid germ cells that contain a single active X chromosome. Two recent publications clarify the kinetics of X-chromosome reactivation (XCR) in vivo and implicate specific epigenetic modifications in the process.
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