StructMAn 2.0 Web: a web server for structural annotation of protein sequences and mutations

Abstract

StructMAn is a method for protein structural annotation. It describes each position of a protein sequence or specific variants in it in terms of their importance for the three-dimensional (3D) structure of the protein and its interactions with other molecules. StructMAn maps, aligns, and aggregates data from experimentally resolved and predicted 3D structures of proteins and their homologs for any given protein sequence and/or a combination of mutations in it. The results provide structural annotation for every amino acid position allowing a detailed structural analysis. Furthermore, StructMAn enables generation of a wide variety of position-specific high-quality structural features that can be leveraged in machine learning applications. With the new web server StructMAn 2.0 Web, we provide a user-friendly way to use StructMAn offering an easy-to-use input interface and a comprehensive visualization for the various results of StructMAn. StructMAn 2.0 Web is available at https://tools.helmholtz-hips.de/structman.