Chelating-Group-Assisted C(sp2)–O Reductive Elimination at the Gold(III) Center

IF 4.9 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-05-01 DOI:10.1021/acs.orglett.5c01053

Avishek Das, Shivanshu Tripathi, Lisa Roy, Nitin T. Patil

引用次数: 0

Abstract

Herein, we demonstrate chelating-group-assisted C(sp²)–O reductive elimination at gold(III) centers. Detailed stoichiometric studies highlighted the importance of a chelating group for achieving successful C–O reductive elimination, paving the way for the development of a catalytic version. The mechanistic investigations, including control experiments, ³¹P NMR, mass spectrometry, and density functional theory (DFT) studies, suggested that the synergistic effect of the ligand and chelating group creates a highly coordinated environment around the Au(III) center to facilitate the C(sp²)–O bond-forming reaction.

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螯合基团辅助C(sp2) -O在金（III）中心的还原消除

在这里，我们证明了螯合基团辅助C(sp2) -O在金（III）中心的还原消除。详细的化学计量学研究强调了螯合基团对成功实现C-O还原消除的重要性，为开发催化版本铺平了道路。通过对照实验、31P核磁共振、质谱分析和密度泛函数理论（DFT）研究表明，配体和螯合基团的协同作用在Au（III）中心周围形成了一个高度协同的环境，促进了C(sp2) -O成键反应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.